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Consider the pentapeptide Ile-Lys-Asp-Phe-Gly and answer the following (use the pKa values in the table): 1. Draw the structure of the predominant form of the pentapeptide at pH = 12. 2. Draw the structure of the Zwitterion form of the pentapeptide. 3. What is the IpH of the peptide?

Consider the pentapeptide Ile-Lys-Asp-Phe-Gly and answer the following (use the pKa values in the table): 1. Draw the structure of the predominant form of the pentapeptide at pH = 12. 2. Draw the structure of the Zwitterion form of the pentapeptide. 3. What is the IpH of the peptide?

Chemistry
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Consider the pentapeptide Ile-Lys-Asp-Phe-Gly and answer the following (use the pKa values in the table): 1. Draw the structure of the predominant form of the pentapeptide at pH = 12. 2. Draw the structure of the Zwitterion form of the pentapeptide. 3. What is the IpH of the peptide? Handwritten solution
Table 2. pka and pl values of the standard amino acids (Lehninger et al., 2005). pKaR (side chain) pKa1 pKa2 pl Amino acid (а-carboxyl) (protonated a-amino) Gly 2.34 9.60 5.97 Ala 2.34 9.69 6.01 Val 2.32 9.62 5.97 Leu 2.36 9.60 5.98 lle 2.36 9.68 6.02 Pro 1.99 10.96 6.48 Phe 1.83 9.13 5.48 5.66 Тyr Trp 2.20 9.11 10.07 2.38 9.39 5.89 Ser 2.21 9.15 5.68 Thr 2.11 9.62 5.87 Сys 1.96 10.28 8.18 5.07 Met 2.28 9.21 5.74 Asn 2.02 8.80 5.41 Gln 2.17 9.13 5.65 Asp 1.88 9.60 3.65 2.77 Glu 2.19 9.67 4.25 3.22 2.18 Lys Arg 8.95 10.53 9.74 2.17 9.04 12.48 10.76 His 1.82 9.17 6.00 7.59
Transcribed Image Text:Table 2. pka and pl values of the standard amino acids (Lehninger et al., 2005). pKaR (side chain) pKa1 pKa2 pl Amino acid (а-carboxyl) (protonated a-amino) Gly 2.34 9.60 5.97 Ala 2.34 9.69 6.01 Val 2.32 9.62 5.97 Leu 2.36 9.60 5.98 lle 2.36 9.68 6.02 Pro 1.99 10.96 6.48 Phe 1.83 9.13 5.48 5.66 Тyr Trp 2.20 9.11 10.07 2.38 9.39 5.89 Ser 2.21 9.15 5.68 Thr 2.11 9.62 5.87 Сys 1.96 10.28 8.18 5.07 Met 2.28 9.21 5.74 Asn 2.02 8.80 5.41 Gln 2.17 9.13 5.65 Asp 1.88 9.60 3.65 2.77 Glu 2.19 9.67 4.25 3.22 2.18 Lys Arg 8.95 10.53 9.74 2.17 9.04 12.48 10.76 His 1.82 9.17 6.00 7.59
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