Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:**Formation and Isoelectric Point (pI) of the Di-peptide Glu-Lys**
**1. Introduction:**
This exercise involves drawing the di-peptide formed from glutamic acid (Glu) and lysine (Lys) at neutral pH, and determining whether its isoelectric point (pI) is acidic, neutral, or basic.
**2. Description of Amino Acids:**
(a) **Lysine (Lys):**
```
H2N O
| ||
H2N-CH- C - OH
|
CH2
|
CH2
|
CH2
|
CH2
|
NH2
```
**Structure:**
- The structure of lysine includes an amino group (H2N) and a carboxyl group (COOH).
- The side chain (R group) is four CH2 groups ending in an amino group (NH2).
(b) **Glutamic Acid (Glu):**
```
H2N O
| ||
H2N-CH- C - OH
|
CH2
|
CH2
|
CH2
|
|C
O |
OH
```
**Structure:**
- The structure of glutamic acid consists of an amino group (H2N) and a carboxyl group (COOH).
- The side chain is two CH2 groups followed by a carboxyl group (COOH).
**3. Formation of Glu-Lys Di-peptide:**
To form the di-peptide Glu-Lys, the carboxyl group of Glu reacts with the amino group of Lys, releasing a molecule of water in a condensation reaction:
```
H2N O H2N O
| || | ||
H2N-CH- C - OH + H2N-CH- C - OH --
| + H2O
CH2 | |
| CH2 CH2
CH2 | |
| CH2 CH2
CH2 | |
| C - NH
COO NH2 -Oh
```
**4. Isoelectric Point (pI) Consideration:**
- The isoelectric
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