Jeer Shakes X Q Chapter 5 - BI ×O Question 6 of Xb Search results XG Proteins calle X C Solved O Side %5463458#/5463458/5/-1nt Score:41.8%O ResourcesGive Up?O HintCheck Answeof 14<>O side-by-SideProteins called molecular chaperones assist in the process ofThere is one position in the signature sequence that can beprotein folding. One class of chaperones found in organismsfrom bacteria to mammals is heat shock protein 90 (Hsp90).All Hsp90 chaperones contain a 10 amino acid signaturesequence that readily allows identification of these proteinsoccupied by any amino acid, although one amino acidappears much more often than any other.in sequence databases.What is this varíable position?Two representations of the Hsp90 signature sequence areshown here.Y-x-[NQHD]-[KHR]-[DE]-[IVAJ-F-[LM]-R-[ED].position number:YSNKE FLRE4Enter the one-letter code for the amino acid that appearsmost often at this variable position.1 2 3 4 5 6 7 8 9 10NCamino acid;Some of the amino acid residues in this sequence areinvariant, meaning they are conserved across all species.2 BIO 312 - Respi.pptx2 Trevar Pinson R.docxShow Allonse.docxD Joel Coen and.pptxDIDD80000F10F11F12FBF9F6F7F4FS%24delete45608.9UPRFHK

Proteins are composed of amino acids, which are bound together by peptide linkage. Amino acids…

Answered: Proteins called molecular chaperones…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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You are studying COVID-19 which infects bat cells through an interaction between a lysine residue on a viral protein with an aspartic acid residue on the bat cell protein. You discover that when the virus made the jump into human cells, the virus mutated the lysine residue to leucine. Based on your knowledge of amino acid chemistry, which amino acid(s) will the leucine most likely interact with? Briefly explain your answer.
A molecular researcher, Dr. Sidra Alkatini, is investigating the manifestation of a disorder in some of her lab mice models, which are lacking production of an important protein necessary for the cellular respiration pathway. The afflicted mice are short lived, and have perpetually low blood glucose levels, no matter how much food they are fed. Through sequencing, the following strand of DNA was produced: 5’ TTC CAA TTA CGC CGC TAT ACG CGC ACC ATG TTA TCA TGT TGG TGG TAG 3’ Given your expertise in genetics, she contacts you, her BFF, to help her understand the sequence and its relation to the genetic disorder she is seeing. 1) What motif in this DNA sequence would serve as the RBS? a Essentially none; this is a eukaryotic sequence, so the RBS will be made up of the methylated G-cap! b CAAT! c ACCATGG! d TATA! 2) Do you notice anything unusual about this transcript? a YES! It is very short! b YES! It is…
What is the order of the polypeptide chain shown in the images provided? Starting at the beginning of translation, determine the order of the amino acids in the polypeptide chain shown in this figure. Choose correct amino acids from the drop-down menu. (The choices from drop down menu are below). 1. (Choices): Leucine, Valine, Methionine 2. Leucine, Valine, Glycine 3. Valine, Methionine, Leucine 4. Methionine, Leucine, Glycine
For each of the following sequences, rank them in order (from best to worst) as sequences that could be used to initiate translation according to Kozak’s rules. GACGCCAUGG GCCUCCAUGC GCCAUCAAGG GCCACCAUGG
In the image below, the blue squiggly line represents a folded protein. There are two particular amino acids that are colored red and black in the protein. The structure of each of these two specific amino acids is shown in the indicated box. A mutation occurs in the gene that encodes the protein illustrated above. The result of this mutation is that one of the amino acids above is substituted with another. Specifically, the amino acid whose structure is shaded red above (the one on the left in the illustration) is replaced by the amino acid shown below. Use this information to answer the two questions that follow. Please answer these questions. 1. Based on this description, indicate which type of mutation occurred: missense, nonsense, silent, or indel 2. How would this mutation affect this protein's structure and function? Explain in 2-4 sentences. Be specific, and be sure to include details of these specific amino acids in your response. (I'm giving you the…
Using sickle-cell anemia as an example, describe what is meant by a molecular or genetic disease. What are the similarities and dissimilarities between this type of a disorder and a disease caused by an invading microorganism?
In studies of the amino acid sequence of wild-type and mutant forms of tryptophan synthetase in E. coli, the following changes have been observed: Determine a set of triplet codes in which only a single-nucleotide change produces each amino acid change.
Posttranslational modifications of proteins do not include: peptide bond formation glycosylation acetylation of N-terminal peptide bond cleavage disulfide bond formation QUESTION 16 14 15 16 streptomycin puromycin 17 18 19 20 Which one of the following antibiotics does NOT function by interfering with the translational/post-translation process tunicamycin penicillin O tetracyclin O O
In HbS, the human hemoglobin found in individuals with sickle-cell anemia, glutamic acid at position 6 in the beta chain is replaced by valine. Q.) Show that one of the glutamic acid codons can be converted to a valine codon by a single substitution mutation (i.e., by changing one letter in one codon).
Given the following diagram of how protein AWESOME1 binds to it's target DNA, describe the potential effects of each of the 5 mutations shown below. The wild-type sequence of a helix #1 is also shown in the blue box, and all the mutations are in helix #1 (see numbers for identifying particular residues). a helix #1 R(1)-V-I-L-Y-F-W-I-M-Y-F-S-H-Y-W-R(16) #1 Predict the consequence of the following mutations: 1) Arg(1) to Glu 2) Arg(1) to Ala 3) Phe(6) to lle 4) Trp(7) to Phe 5) Met(9) to Pro in

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