A molecular researcher, Dr. Sidra Alkatini, is investigating the manifestation of a disorder in some of her lab mice models, which are lacking production of an important protein necessary for the cellular respiration pathway. The afflicted mice are short lived, and have perpetually low blood glucose levels, no matter how much food they are fed. Through sequencing, the following strand of DNA was produced: 5’ TTC CAA TTA CGC CGC TAT ACG CGC ACC ATG TTA TCA TGT TGG TGG TAG 3’ Given your expertise in genetics, she contacts you, her BFF, to help her understand the sequence and its relation to the genetic disorder she is seeing. 1) Now that you have seen the sequence and identified some of the major motifs it contains, what are going to tell Dr. Alkatini about in relation to the genetic disorder she is seeing? a “Listen, Doc, it is clear there is no STOP signal in the last codon place where it normally should be.” b “Listen, Doc, the fact that there is no intron delineating motif means the gene is not being processed during splicing, so there is no way for it to be expressed.” c “Listen, Doc, I am confident that there is nothing wrong with this sequence so I imagine it might be a problem associated with the ribosomes." d “Listen, Doc, I am confident that you dealing with an early NONSENSE mutation, which is causing a LOF.”

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

See similar textbooks

Related questions

Concept explainers

Question

A molecular researcher, Dr. Sidra Alkatini, is investigating the manifestation of a disorder in some of her lab mice models, which are lacking production of an important protein necessary for the cellular respiration pathway. The afflicted mice are short lived, and have perpetually low blood glucose levels, no matter how much food they are fed. Through sequencing, the following strand of DNA was produced:

5’ TTC CAA TTA CGC CGC TAT ACG CGC ACC ATG TTA TCA TGT TGG TGG TAG 3’

Given your expertise in genetics, she contacts you, her BFF, to help her understand the sequence and its relation to the genetic disorder she is seeing.

Now that you have seen the sequence and identified some of the major motifs it contains, what are going to tell Dr. Alkatini about in relation to the genetic disorder she is seeing?

“Listen, Doc, it is clear there is no STOP signal in the last codon place where it normally should be.”

“Listen, Doc, the fact that there is no intron delineating motif means the gene is not being processed during splicing, so there is no way for it to be expressed.”

“Listen, Doc, I am confident that there is nothing wrong with this sequence so I imagine it might be a problem associated with the ribosomes."

“Listen, Doc, I am confident that you dealing with an early NONSENSE mutation, which is causing a LOF.”

Definition Definition Set of metabolic processes and reactions that produce energy from organic substances such as glucose. Cellular respiration takes place in the organism’s cells, where the chemical energy from nutrients or molecules of oxygen is converted into adenosine triphosphate (ATP). Cellular respiration that occurs in the presence of oxygen is called aerobic respiration; in the absence of oxygen, it is called anaerobic respiration.

Expert Solution

Trending now

This is a popular solution!

Step by step

Solved in 4 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions