Problem 7: A patient with with uveal melanoma is treated at a cyclotron facility with energetic protons directed at a tumor in their eye, with a dose of 1.0 Gy administered over five sessions, What is the equivalent dose in Sv to the tumor?
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(RBE) value of 20 for the a radiation, calculate the equivalent dose In
miner in that year
Problem 7: A patient with with uveal melanoma
is treated at a cyclotron facility with energetic
protons directed at a tumor in their eye, with a
dose of 1.0 Gy administered over five sessions,
What is the equivalent dose in Sv to the
tumor?
A
6
Type of Radiation
O
Sv
X-rays
7-rays
/ rays > 32 kev
rays <32 ke V
Neutrons, thermal to slow (< 20 keV)
Neutrons, fast (1 – 10 MeV)
Protons (1 - 10 MeV)
a-rays from radioactive decay
to the lungs of the
17
10 (body), 32 (eyes)
10 (body), 32 (cycs)
20"
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- Please show dimensional analysis to solveShow computation 4. Mrs. Potter has chronic bronchitis with an infection. To treat the infection, the physician prescribes gatifloxacin (Tequin) 400 mg to infuse in over 2 hours. The pharmacy delivers gatifloxacin 400 mg in a 200-mL bag of NS. What should be the rate of the infusion, in milliliters per hour, to complete the Tequin infusion? 5. The physician prescribes 1,000 mL of D5 NS to infuse at a rate of 200 mL/h. The nurse started the infusion at 5pm. She expects the IVF to be infused completely at what time?Questions 10, 11, and 12 pertain to the following scenario: A patient (140 lb; 5'4") receives oxaliplatin 130 mg/m² infused over a 6-hour period. The IV admixture is made by adding the volume of oxaliplatin solution containing the dose into a 250 mL bag of D5W. 10. How many milliliters from a 5 mg/mL vial should be added to 250 mL of D5W? 11. Calculate the rate of oxaliplatin administration, in micrograms per minute.* Round to the nearest whole number. 12. What drip rate would you recommend if a 20-drop set is used?
- BME 3Chemistry The patient in the previous example received 1000 mg of an antibiotic every 6 hours byrepetitive IV injection. The drug has an apparent volume of distribution of 20 L and anelimination half-life of 3 hours. Calculate:(a) the plasma drug concentration, Cp at 3 hours after the second dose(b) the steady-state plasma drug concentration, Cpss at 3 hours after the last dose (c) Cpmax(d) Cpmin(e) Cpaverage.Medication Calculations 1. The medication order is for Motrin 0.6 g and the pharmacy delivered Motrin 400mg per tablet. What dose will you give? 2. The medication order is for Tylenol 140 mg PO Q4H for a temp above 101°. Tylenol comes 100 mg/5 mL. How much will you give in each dose? 3. The physician has ordered Haldol 3mg IM for your patient. Haldol is available on your unit in 2 mL ampules containing 5 mg/1 mL How many mL will you administer to the patient? 4. The physician has ordered 25 mg Solumedrol IV. Available is 40 mg/2mL. How many mL will you give? 5. You have received an order for atropine 400 mcg to be given subcutaneously STAT. The multi-dose vial is labeled 1 mg/mL. How many mL will you give? 6. 15 mg of Torecan is ordered; available solution contains 10 mg/2mL. How many mL will you give? Exercise 2.. True or False: Are You Administering the Medication Correctly? 1. 2. 3. 4. 5. Administer liquid medication to a child in a lying position with head turned to side. The best…
- Dosage Calculations27. A baby weighs 3.2 kg. The dose calls for 0.4 mg/kg. What is the dosage? Drug Calculations28. How much active ingredient in 20 cc of a 15% solution? 29. You have 1:1000 concentration of epinephrine. How many mLs do you need to draw up if you want togive 45 mg of the drug? 30. How many mg of an active ingredient are in 4 mL of a 0.4% solution? 31. How many mLs do you need to give to get 20 mg of a 350mg/20mL dose? 32. Albuterol syrup is available in 2mg/5 mL. How much do you take if 6 mg is ordered? 33. Promazine HCL comes as 500 mg/10 mL. How many milliliters are needed to give a 150 mg dose? 34. 4 mg of morphine sulfate is ordered. you have a vial with 10mg/mL. How many mLs do you need todeliver? 35. Albuterol syrup is available in a 2 mg/ 5 mL concentration. If a dose schedule of 0.1 mg/kg is used, howmuch syrup is needed for a 30 kg. child? 36. A pediatric dose of oxytetracycline of 100 mg is ordered. The dosage form is an oral suspensioncontaining 125 mg/5cc.…Practice question 1B) Mutations in the signalling pathways depicted above have been associated with an increased incidence of several types of cancer. Individuals with the se cancers may be treated with one of the following chemotherapeutic drugs. Complete the table below about their me chanisms of action. In which cellular Which process is targeted first compartment/structure/organelle by this drug? Drug Drug's mechanism of action does this proce ss occur? (replica tion, mitosis, transcription, translation, or If more than 1 location, be sure to specify ALL relevant locations. none of the above)? A Inhibits microtubule assembly Create inter- or intra-strand crosslinking in DNA preventing strand separation Inhibits synthesis of non-essential amino acids Drug CH3 HN HN PPPO O N. PPPO O OH OH 5-deoxythymydine triphosphate (DTTP) 5-deoxyuridine triphosphate (DUTP)Match the methods discussed to the description of what it would be used for. HPLC-UV Visual range standard curve Affinity chomatography UV analysis of protein fractions Gel filtration Ion Exchange SDSPAGE…
- explain why? Amikacin is an aminoglycoside antibiotic. Its elimination half lifeand the apparent volume of distribution are reported to be 3 hand 0.25 L/kg respectively. Deternimne the amikacin placmaconcentration at 4 h following an IV bolus dose of 6.25 mg/kga. 9,923 microgram/Lb. 6,25 mg/Lc. 9,923 mg/Ld. 9,923 mg/h Ciprofloxacin (Cipro) is a fluoroquinolone antibotic. Itselimination half life and the apparnt volume of distribution are 4h and 2,25 L/kg respectively. The IV bolus administration ofciprofloxacin yielded the plasma concentration 1,048microgram/mL at 6 h. Determine the administered dose ofCipro?a. 2,963 mg/kgb. 6,667 mg/kgc. 2,963 microgram/mLd. 5.0 mgA 45-year-old woman has been receiving radiation therapy for breast cancer. Explain in not more than 100 words, the effects of ionizingquestion: Increasing the rate of breathing is a more effective strategy to increase alveolar ventilation than increasing depth of breathing. answer should clearly state whether or not the statement is correct and then concisely explain why. the answer should be like a few sentences and address all of the points in the statement. Here is an example: Both transmembrane carrier proteins and transmembrane channel proteins can mediate active transport of a hydrophilic solute through a cell plasma membrane. This statement is incorrect. Movement of a solute through a channel protein is always passive, whereas carrier-mediated transmembrane transport can be either passive or active. A transmembrane channel protein creates a pore through the membrane allowing for simple diffusion of a hydrophilic solute down a concentration gradient through the membrane. In contrast, transmembrane carrier protein interacts with and 'escorts' a hydrophilic solute through the membrane and is capable of…