Mutations in the signalling pathways depicted above have been associated with an increased incidence of several types of cancer. Individuals with the se cancers may be treated with one of the following chemotherapeutic drugs. Complete the table below about their mechanisms of action. In which cellular Which process is targeted first compartment/structure/organelle by this drug? Drug Drug's mechanism of action does this proce ss occur? (re plication, mitosis, transcription, translation, or If more than 1 location, be sure to specify ALL re levant locations. none of the above)? A Inhibits microtubule assembly Create inter- or intra-strand crosslinking in DNA pre venting strand separation Inhibits synthesis of non-essential amino acids Drug CH3 HN HN 'N' PPPO O PPPO O OH OH 5-deoxyuridine triphosphate (dUTP) 5-deoxythymydine triphosphate (dTTP)

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Practice question 1B)
Mutations in the signalling pathways depicted above have been associated with an increased
incidence of several types of cancer. Individuals with the se cancers may be treated with one of the
following chemotherapeutic drugs. Complete the table below about their me chanisms of action.
In which cellular
Which process
is targeted first compartment/structure/organelle
by this drug?
Drug
Drug's mechanism of action
does this proce ss occur?
(replica tion,
mitosis,
transcription,
translation, or
If more than 1 location, be sure to
specify ALL relevant locations.
none of the
above)?
A
Inhibits microtubule assembly
Create inter- or intra-strand crosslinking
in DNA preventing strand separation
Inhibits synthesis of non-essential
amino acids
Drug
CH3
HN
HN
PPPO O
N.
PPPO O
OH
OH
5-deoxythymydine
triphosphate (DTTP)
5-deoxyuridine
triphosphate (DUTP)
Transcribed Image Text:Practice question 1B) Mutations in the signalling pathways depicted above have been associated with an increased incidence of several types of cancer. Individuals with the se cancers may be treated with one of the following chemotherapeutic drugs. Complete the table below about their me chanisms of action. In which cellular Which process is targeted first compartment/structure/organelle by this drug? Drug Drug's mechanism of action does this proce ss occur? (replica tion, mitosis, transcription, translation, or If more than 1 location, be sure to specify ALL relevant locations. none of the above)? A Inhibits microtubule assembly Create inter- or intra-strand crosslinking in DNA preventing strand separation Inhibits synthesis of non-essential amino acids Drug CH3 HN HN PPPO O N. PPPO O OH OH 5-deoxythymydine triphosphate (DTTP) 5-deoxyuridine triphosphate (DUTP)
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