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Problem 1. One of the consequences of ethanol addiction is fatty liver disease, an illness in which liver cells accumulate large amounts of triacylglycerols, the esters derived from glycerol and fatty acids. Ethanol is oxidized in the cytoplasm of liver cells by alcohol dehydrogenase and aldehyde dehydrogenase to yield acetate and 2 NADH. Acetate is then transported into the mitochondrion, where it is converted to acetyl-CoA and metabolized in the citric acid cycle. A. Give a reason based on the products of ethanol metabolism and the electron transport chain for high energy charge in the cell B. Give a reason to expect high glucose-6-phosphate (G6P) concentration in the cell given high-energy charge. C. How would excess G6P concentration contribute to the reducing potential required for fatty acid synthesis?

Problem 1. One of the consequences of ethanol addiction is fatty liver disease, an illness in which liver cells accumulate large amounts of triacylglycerols, the esters derived from glycerol and fatty acids. Ethanol is oxidized in the cytoplasm of liver cells by alcohol dehydrogenase and aldehyde dehydrogenase to yield acetate and 2 NADH. Acetate is then transported into the mitochondrion, where it is converted to acetyl-CoA and metabolized in the citric acid cycle. A. Give a reason based on the products of ethanol metabolism and the electron transport chain for high energy charge in the cell B. Give a reason to expect high glucose-6-phosphate (G6P) concentration in the cell given high-energy charge. C. How would excess G6P concentration contribute to the reducing potential required for fatty acid synthesis?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Problem 1. One of the consequences of ethanol addiction is fatty liver disease, an illness in which liver cells accumulate large amounts of triacylglycerols, the esters derived from glycerol and fatty acids. Ethanol is oxidized in the cytoplasm of liver cells by alcohol dehydrogenase and aldehyde dehydrogenase to yield acetate and 2 NADH. Acetate is then transported into the mitochondrion, where it is converted to acetyl-CoA and metabolized in the citric acid cycle. A. Give a reason based on the products of ethanol metabolism and the electron transport chain for high energy charge in the cell B. Give a reason to expect high glucose-6-phosphate (G6P) concentration in the cell given high-energy charge. C. How would excess G6P concentration contribute to the reducing potential required for fatty acid synthesis?
Transcribed Image Text:Problem 1. One of the consequences of ethanol addiction is fatty liver disease, an illness in which liver cells accumulate large amounts of triacylglycerols, the esters derived from glycerol and fatty acids. Ethanol is oxidized in the cytoplasm of liver cells by alcohol dehydrogenase and aldehyde dehydrogenase to yield acetate and 2 NADH. Acetate is then transported into the mitochondrion, where it is converted to acetyl-CoA and metabolized in the citric acid cycle. A. Give a reason based on the products of ethanol metabolism and the electron transport chain for high energy charge in the cell B. Give a reason to expect high glucose-6-phosphate (G6P) concentration in the cell given high-energy charge. C. How would excess G6P concentration contribute to the reducing potential required for fatty acid synthesis?
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