Multiple answers are accepted for this question Which of the following statements are FALSE?Multiple answers: Multiple answers are accepted for this questionSelect one or more answers and submit. For keyboard navigation... SHOW MORE VYou have isolated two species of bacteria. One grows best at 20 °C andthe other grows best at 40 °C. The bacteria grown at 20 °C will havethe higher saturated/unsaturated fatty acid ratio.aTay-Sachs disease is a neurological disorder caused by a deficiency inHexosaminidase A which is required sphingolipid metabolism. If bothparents are heterozygous the probability of having a child with Tay-Sachs disease is 50 %.Cytosolic NADH in muscle donates 2 electrons to FAD by the GlycerolPhosphate Shuttle.Cyanide blocks electron transfer in the electron transport systemdresulting in no loss of proton-motive force.eThe citric acid cycle transfers 6 electrons to 3 NAD* and 1 FAD.The energy available from redox reactions is due to differences in theelectron affinity of two reactants: compounds that accept electronsf(oxidants) are reduced in the reaction, and compounds that donateelectrons (reductants) are oxidized. Please save all answers. Questions that you save can stillEave 1 UNSAVED ANSWER -SAVE ALL ANSWERSTay-Sachs disease is a neurological disorder caused by a deficiency inHexosaminidase A which is required sphingolipid metabolism. If bothparents are heterozygous the probability of having a child with Tay-Sachs disease is 50 %.Cytosolic NADH in muscle donates 2 electrons to FAD by the GlycerolPhosphate Shuttle.Cyanide blocks electron transfer in the electron transport systemd.resulting in no loss of proton-motive force.The citric acid cycle transfers 6 electrons to 3 NAD* and 1 FAD.eThe energy available from redox reactions is due to differences in theelectron affinity of two reactants: compounds that accept electronsf(oxidants) are reduced in the reaction, and compounds that donateelectrons (reductants) are oxidized.E1 (Pyruvate Dehydrogenase) decarboxylates pyruvate resulting ingformation of hydroxyethyl-TPP with release of CO,.El reacts with the disulfide of the lipoamide group on the N-terminaldomain of the E2 subunit forming thioester-linked acetyl-dihydrolipoamide.E3 is a NAD-linked dehydrogenase that reoxidizes dihydrolipoic acid toilipoic acid.

Tay-Sachs disease is an autosomal recessive disease. It occurs when both the alleles of the HEXA genes on chromosome 15 of an individual are mutated. HEXA codes for the alpha subunit of the enzyme . The enzyme is responsible for the breakdown of the ganglioside GM2 (a sphingolipid). Ganglioside GM2 accumulates in the brain and spleen of individuals with the disease, leading to the symptoms of Tay-Sachs disease including paralysis, developmental retardation, loss of eye sight and death by the early age of 3 or 4 years.There is a higher chance of the plasma membrane of the bacteria living in colder conditions (200C) of becoming too rigid. To prevent this, their plasma membrane will contain more unsaturated fatty acids, when compared to the plasma membrane of the bacteria living in higher temperatures (400C). So, the saturated/unsaturated fatty acid ratio of bacteria living in 200 C will be lower compared to the bacteria living in 400C. Hence statement (a) is false.If both parents are heterozygous (i.e. carriers) for the Tay-Sachs disease, they will have the genotype of 'Rr'. 'R' being the normal allele and 'r' being the mutated disease causing allele. Upon crossing between two Rr genotypes, we get 1 RR, 2 Rr and 1 rr. Since Tay-Sachs disease is automosomal recessive, both alleles have to be mutated for the individual to have the disease. So RR child is normal, Rr children are carriers and the rr child will have the Tay-Sachs disease. So, the probability of a child having Tay-Sachs disease is 25% when both parents are heterozygous for the disease. There is a 25% chance of the child being normal, 50% chance of being a carrier and 25% chance of having the disease. Hence statement (b) is false.The NADH produced in the cytosol can pass its 2 electrons to FAD via the Glycerol 3-phosphate shuttle. Hence statement (c) is true.Cyanide is a non-competitive inhibitor of Complex IV of ETC (Electron Transport Chain). It binds to the iron cofactor in the complex and prevents the passage of electrons to O2. This blocks the flow of electrons in ETC, which will lead to complex IV being unable to pump protons to the Inter Membrane Space (IMS). This will decrease the proton-motive force. Hence statement (d) is false.The citric acid cycle transfers 2 electrons each to 3 NAD+ and 1 FAD. So, the total number of electrons passed is 8, not 6. Hence statement (e) is false.Spontaneous (energy releasing) redox reactions take place due to the difference in the electron affinities of the 2 reactants that are participating in the reaction. One of the reactants donates electron(s) to the other reactant. The one that donates electrons is called reductant and it gets oxidized (oxidation is the loss of electrons). The one that accepts electrons is called oxidant and it gets reduced (reduction is the gain of electrons). Hence statement (f) is true.The pyruvate dehydrogenase complex is an enzyme complex comprised of 3 enzymes (each enzyme can be called as a subunit too); Pyruvate dehydrogenase (E1), Dihydrolipoyl transacetylase (E2) and Dihydrolipoyl dehydrogenase (E3). E1 is responsible for the decarboxylation of pyruvate that results in the formation of hydroxyethyl-TPP and release of CO2. The N-terminal domain of E2 has a lipoamide group. E1 catalyzes the transfer of the two electrons and the acetyl group to the oxidized disulfide end of the lipoamide. This results in the formation of thioester-linked acetyl-dihydrolipoamide. E3 has FAD as cofactor which accepts 2 electrons from the reduced dihydrolipoic acid of E2. This reoxidizes dihydrolipoic acid to lipoic acid. The FADH2 hence formed then donates the 2 electrons to a NAD+ linked to E3, completing the process. Hence, statements (g), (h) and (i) are all true.The false statements are (a), (b), (d) and (e).

Science

Biochemistry

Which of the following statements are FALSE? Select one or more answers and submit. For keyboard navigation... SHOW MORE ✓ a b C d e Multiple answers: Multiple answers are accepted for this question f You have isolated two species of bacteria. One grows best at 20 °C and the other grows best at 40 °C. The bacteria grown at 20 °C will have the higher saturated/unsaturated fatty acid ratio. Tay-Sachs disease is a neurological disorder caused by a deficiency in Hexosaminidase A which is required sphingolipid metabolism. If both parents are heterozygous the probability of having a child with Tay- Sachs disease is 50%. Cytosolic NADH in muscle donates 2 electrons to FAD by the Glycerol Phosphate Shuttle. Cyanide blocks electron transfer in the electron transport system resulting in no loss of proton-motive force. The citric acid cycle transfers 6 electrons to 3 NAD* and 1 FAD. The energy available from redox reactions is due to differences in the electron affinity of two reactants: compounds that accept electrons (oxidants) are reduced in the reaction, and compounds that donate electrons (reductants) are oxidized.

Which of the following statements are FALSE? Select one or more answers and submit. For keyboard navigation... SHOW MORE ✓ a b C d e Multiple answers: Multiple answers are accepted for this question f You have isolated two species of bacteria. One grows best at 20 °C and the other grows best at 40 °C. The bacteria grown at 20 °C will have the higher saturated/unsaturated fatty acid ratio. Tay-Sachs disease is a neurological disorder caused by a deficiency in Hexosaminidase A which is required sphingolipid metabolism. If both parents are heterozygous the probability of having a child with Tay- Sachs disease is 50%. Cytosolic NADH in muscle donates 2 electrons to FAD by the Glycerol Phosphate Shuttle. Cyanide blocks electron transfer in the electron transport system resulting in no loss of proton-motive force. The citric acid cycle transfers 6 electrons to 3 NAD* and 1 FAD. The energy available from redox reactions is due to differences in the electron affinity of two reactants: compounds that accept electrons (oxidants) are reduced in the reaction, and compounds that donate electrons (reductants) are oxidized.

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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