Postsynaptic synapses that have NMDA receptors but not AMPA/kainate receptors on the postsynaptic membrane are called 'silent synapses' because they lack postsynaptic responses at resting membrane potential. Why do these synapses not have postsynaptic responses? Under what conditions could you detect a postsynaptic response from the silent synapse (synapses lacking AMPA/kainate receptors)?
Postsynaptic synapses that have NMDA receptors but not AMPA/kainate receptors on the postsynaptic membrane are called 'silent synapses' because they lack postsynaptic responses at resting membrane potential. Why do these synapses not have postsynaptic responses? Under what conditions could you detect a postsynaptic response from the silent synapse (synapses lacking AMPA/kainate receptors)?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Transcribed Image Text:5. Postsynaptic synapses that have NMDA receptors but not AMPA/kainate receptors on the
postsynaptic membrane are called 'silent synapses' because they lack postsynaptic
responses at resting membrane potential. Why do these synapses not have postsynaptic
responses? Under what conditions could you detect a postsynaptic response from the
silent synapse (synapses lacking AMPA/kainate receptors)?
Expert Solution
Step 1
A brief shift in the electric polarisation of a nerve cell's membrane is called a postsynaptic potential (PSP) (neuron). The postsynaptic potential is the outcome of chemical transfer of a nerve impulse at the synapse (neuronal junction), and it might lead to the firing of a new impulse.
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