Why was the postsynaptic CA1 neuron voltage clamped to +30 mV?  To stimulate insertion of AMPA receptors into the postsynaptic membrane To move NDA receptors into the synapse from an extrasynaptic site To cause coordination between the pre- and postsynaptic neuron To increase conductance of the NMDAR by removing the Mg?* block To stimulate AMPA receptors, which in turn activate NMDA Rs Explain the results obtained when AP5 was applied while the neuron was held at +30 mV. What is the interpretation of the result?

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Why was the postsynaptic CA1 neuron voltage clamped to +30 mV? 

  1. To stimulate insertion of AMPA receptors into the postsynaptic membrane
  2. To move NDA receptors into the synapse from an extrasynaptic site
  3. To cause coordination between the pre- and postsynaptic neuron
  4. To increase conductance of the NMDAR by removing the Mg?* block
  5. To stimulate AMPA receptors, which in turn activate NMDA Rs

    Explain the results obtained when AP5 was applied while the neuron was held at +30 mV. What is the interpretation of the result?

71) Figure below illustrates the data from one of the original experiments that showed evidence
for 'silent synapses'. Stimulation of CA3 axons resulted in no postsynaptic response when
the CA1 neuron was voltage-clamped at -60 mV.
30₁
+30 mV
20
10
response amplitude (PA)
-30
-60 mV
0 100
a) Why was the postsynaptic C
AP5
200 300 400 600 700
stimulus number
Transcribed Image Text:71) Figure below illustrates the data from one of the original experiments that showed evidence for 'silent synapses'. Stimulation of CA3 axons resulted in no postsynaptic response when the CA1 neuron was voltage-clamped at -60 mV. 30₁ +30 mV 20 10 response amplitude (PA) -30 -60 mV 0 100 a) Why was the postsynaptic C AP5 200 300 400 600 700 stimulus number
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