pO2 intissuesp02 inlungs1.00Oxygen-bindingcurves for normalNormal Hbhemoglobin, 50%carboxyhemoglobin,and hemoglobin from0.8an anemic individual.0.6Y50% COHB0.4-Anemic individual0.24812pO2 (kPa)Box 5-1 Figure 2Lehninger Principles of Biochemistry, Seventh EditionO 2017 W. H. Freeman and Companyr aye i UIEI. Answer the following questions. Do not forget the units.1) From the binding curve for normal Hb shown above, what is the Ka of normal hemoglobin?

The oxygen-dissociation curve shows the affinity of oxygen with the hemoglobin protein. The process…

Answered: pO2 in tissues p02 in lungs 1.00…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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O, saturation curve is shown beloww for hemoglobin at various pHs. Detail this Bohr effect from the molecular perspective. Be sure to include discussion of what causes this (i.e. specific amino acids), why the curves are right shifted with decreasing pH, and why this is logical in delivery of 02 to areas of higher demand. 100 Myoglobin 80- pH 7.6 60 pH 7.4 pll 7.2 40- pH 7.0 pH 6.8 20- Venous 0- 0. 20 10 60 80 Percent saturation
Could you please help me with this. Case Study: Patient Barry King is a 27-year-old, asthma patient with COVID-19, who now needs Mechanical ventilation due to respiratory failure related to complications from COVID. He currently weighs 75kg. His current vitals are as follows: RR-24, Breath sounds- coarse crackles in both lungs. His temperature is 102.3, BP- 152/100, HR- 115 bpm, FiO2 on 50% high flow oxygen and ABG results are:pH- 7.29, PACO2-58, PAO2-49, HCO3-23. The MD wants you to suggest ventilator orders for RT to carry out. Please write reasonable orders and defend your order (include Vt, RR, Mode, PEEP, FiO2 and other procedures or orders that would help).
Studies of oxygen transport in pregnant mammals show that the O2-saturation curves of fetal and maternal blood are markedly different when measured under the same conditions. Fetal erythrocytes contain astructural variant of hemoglobin, HbF, consisting of two α and two γ subunits (α2 γ2 ), whereas maternal erythrocytes contain HbA (α2β2).(a) Which hemoglobin has a higher affinity for oxygen under physiological conditions, HbA or HbF? Explain.(b) What is the physiological significance of the different O2 affinities?(c) When all the BPG is carefully removed from samples of HbA and HbF, the measured O2 -saturation curves (and consequently the O2 affinities) are displaced to the left. However, HbA now has a greater affinity for oxygen than does HbF. When BPG is reintroduced, the O2 -saturation curves return to normal, as shown in the graph. What is the effect of BPG on the O2 affinity of hemoglobin? How can the above information be used to explain the different O2 affinities of fetal and…
00 %24 w/ Charles' Law Change the simulation to "Charles' Law" by clicking the tab at the top of the screen it will be shown in white. You should see the picture below on your screen. 1. Which one of the three variables: Pressure, Volume or Temperature cannot be changed in Charles' Law? This varlable is considered a constant. 1. a. Using the Temperature controls, increase the temperature of the gas. What changes do you observe in the behavlor of the particles of the gas while the temperature is increased? b. Continue to increase the temperature value until T, = 44K. Using the equation for Charles' law, calculate the volume of the gas at this increased temperature. Check your final answer for part b by clicking the calculate button next to V2: c. Based on the final value calculated in part b) is Charles' law considered a direct or an indirect relationship between the variables? Explain your cholce with reasoning. 1. 2. Press the reset button at the top right of the screen. Using the…
A 158lb adult male diagnosed with endocarditis has an order for gentamicin 3mg/kg/day IV in 2 divided doses, in addition to vancomycin. The Gentamicin is available in 2 mL vials containing 40mg/mL. The facility protocol is to round the gentamicin dose to the nearest 10mg, then calculate the volume of solution to the nearest tenth mL. How many mL will administer per dose?
PTP1B Substrate kcat Km kcat/Km UM 10-7 x (s-1 M) DADEPYLIPQQG DADAPYLIPQQG DAAEPYLIPQQG AAAAPYLIPQQG 44.6 + 1.8 39.8 + 0.32 3.9 + 0.9 13.7 + 0.46 1.1 + 0.25 0.29 + 0.01 35.3 + 0.22 6.6 ± 0.22 0.53 + 0.02 34.7 + 0.25 52.7 ± 0.7 0.066 + 0.001 (d) (. ) The units for kcat/KM in the above are given according to standard scientific notation. On this basis what is the value of this kinetic parameter for the DADEPYLIPQQG substrate?
If normal plasma pH is 7.4 and normal [CO2) is 1.2 mM, what is the normal (HCO321? The pK9 for this system is 6.1. Phosphoric acid (H3PO4) has three dissociable protons, with the pK,'s shown below. Which form of phosphoric acid predominates in a solution at pH 4? Explain your answer. Acid H3POA 2.14 H2PO4 6.86 HPO,2- 12.4
Chemistry Red cells have a volume of ~86 fL. If the concentration of hemoglobin in red cells is ~330 g/L and its Mr is 64,500 b) In the generation of a red cell, the synthesis of all the hemoglobin molecules of the cell takes about 40 h. How many hemoglobin molecules are synthesized in one second per red cell? c) How many subunits (monomers) of hemoglobin are produced in one minute?
1.12 At elevated altitudes, the body adapts to the reduced barometric pressure to extract sufficient oxy- gen to permit normal metabolic functions and do work. For example, at an altitude of 3,650 m (close to 12,000 feet above sea level) the barometric pressure drops to 485 mmHg. For an oxygen pressure drop in the lungs of 30 mmHg, determine the oxygen uptake rate for a respiration rate of 20 breaths per minute. Estimate the oxygen saturation in venous blood if the hematocrit rises to 0.60 and the partial pressure of oxygen blood is at a partial pressure equal to 98% of the alveolar level.
On the right the Hill plot com- (b) pares the O2 binding properties of Hb Ya- kima with those of HbA in 0.1 M NaCl buff- Hb-Yakima ered to pH 7 with 0.01 M bis-Tris. Focus first on the line for "stripped Hb". This is the term for hemoglobin isolated from erythro- cytes with removal of all organic phosphate molecules that might bind to the protein in RBCS. You can see that 2,3-bisphospho- glycerate (BPG; labeled DPG according to old terminology) does not alter the O2 bind- ing affinity of Hb Yakima in contrast to HbA (although it was shown that BPG did bind to the deoxyHb Yakima molecule). Also, Hb Yakima is associated with markedly decreased allostery in the absence and presence of BPG, in comparison to HbA. IHP = inositol hexaphosphate, an artificial allosteric modifying ligand that binds more tightly than BPG. stripped Hb Hb-A •DPG +DPG n= 1.0 n = 2.3 n=2,5 +THP +IHP 0.5 0.5 1 5 10 50 po, ( mm Hg ) %3D On the right is a diagram copied from the lecture handout "Hemoglobin and Allo-…
A 42 year old man is admitted to the hospital with the sudden onset of dyspnea with clear lungs and a normal chest xray. He has just been on a flight from Australia to New York City. The blood gas values are as follows: pH 7.56, pCO2 16, pO2 80, 95% saturation What is this person’s A-a gradient?
13. 0.9% (m/v) NaCI solution and 5% (m/v) glucose solution are both isotonic to red blood cells. SHOW your work and watch sig figs & units. c. convert the concentration from M to % (m/v) for a 0.342 M NaC solution. (HINT: convert to g/ml and then multiple by 100%)

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