1. The diagram on the right compares the O2 binding prop- erties of normal adult hemoglobin (HbA) to those of one dubbed Hb Great-Lakes characterized by the mutation Leu(368) His. In the dia- gram Y = fraction of heme groups with bound O2, and pO2, the par- tial pressure of O2 above the solution, is measured in units of torr or mmHg. Draw the corresponding Hill plot, being careful to reproduce graph- ically the dissociation equilibrium constant for O2 binding (K0₂) for y each hemoglobin and to show the difference in the extent of allo- stery or cooperativity of subunit interaction in each type of hemo- globin. You need draw only the central, linear portion of the Hill plot. State what is the likely magnitude of the Hill constant (n) for HbA from your reading and state what is the likely range of the magni- tude of the Hill coefficient for Hb Great Lakes. 1.0 0.8 0.6 0.4 0.2 0 Hb Great Lakes 10 Hb A 1 1 20 30 40 pO₂ (torr) 1 50 1 60

1. The diagram on the right compares the O2 binding prop- erties of normal adult hemoglobin (HbA) to those of one dubbed Hb Great-Lakes characterized by the mutation Leu(368) His. In the dia- gram Y = fraction of heme groups with bound O2, and pO2, the par- tial pressure of O2 above the solution, is measured in units of torr or mmHg. Draw the corresponding Hill plot, being careful to reproduce graph- ically the dissociation equilibrium constant for O2 binding (K0₂) for y each hemoglobin and to show the difference in the extent of allo- stery or cooperativity of subunit interaction in each type of hemo- globin. You need draw only the central, linear portion of the Hill plot. State what is the likely magnitude of the Hill constant (n) for HbA from your reading and state what is the likely range of the magni- tude of the Hill coefficient for Hb Great Lakes. 1.0 0.8 0.6 0.4 0.2 0 Hb Great Lakes 10 Hb A 1 1 20 30 40 pO₂ (torr) 1 50 1 60

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

See similar textbooks

Similar questions

Could You explain how Microsytic and macrosytic anemia is caused by beta thalasemia, or iron defiencny What are the diffrences and similarities in there differenainal diagnoises
A 42 year old man is admitted to the hospital with the sudden onset of dyspnea with clear lungs and a normal chest xray. He has just been on a flight from Australia to New York City. The blood gas values are as follows: pH 7.56, pCO2 16, pO2 80, 95% saturation What is this person’s A-a gradient?
12. If the MW of human hemoglobin is 64,000g/mole, and its D, is 6.9X10’ cm?/s, what is its s value in Svedbergs ?
5b
Question 4 Explain all the steps involved in “positive cooperativity”, enabling oxygen binding to hemoglobin.
A 42 year old man is admitted to the hospital with the sudden onset of dyspnea with clear lungs and a normal chest xray. He has just been on a flight from Australia to New York City. The blood gas values are as follows: pH 7.56, pCO2 16, pO2 80, 95% saturation What is this person’s A-a gradient?