(a) (' . Hill plots. Label the axes and indicate on both the plot above and the Hill plot where the value of the dissociation equilibrium constant Ka for O2 binding is defined for 0 and 100 Torr of dichloromethane For the curves at 0 and 100 Torr of dichloromethane, draw their equivalent in the form of Ка Hb(O2)n nO2 +

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5. Anesthetic gases used in surgery are known to bind to the hemoglobin molecule in red blood cells.
The diagram below illustrates O2 binding curves of normal human HbA in the presence of the anesthetic
gas dichloromethane (DCM).
O UNTREATED
100
a Dсм 23 Torr
Symbols:
в Dсм 50 Torr
x DCM I00 Torr
o, 0 Torr DCM;
O, 23 Torr DCM
A, 50 Torr DCM
x, 100 Torr DCM.
80
60
40
(1 Torr = 1 mm Hg.)
20
The solutions
were
buffered to pH 7.4.
0.5
1.0
1.5
2.0
log p02
(a) (*
Hill plots. Label the axes and indicate on both the plot above and the Hill plot where the value of the
dissociation equilibrium constant Ka for O2 binding is defined for 0 and 100 Torr of dichloromethane
For the curves at 0 and 100 Torr of dichloromethane, draw their equivalent in the form of
Kd
Hb(O2)n
Hb
+
nO2
% OXYGENATION
Transcribed Image Text:5. Anesthetic gases used in surgery are known to bind to the hemoglobin molecule in red blood cells. The diagram below illustrates O2 binding curves of normal human HbA in the presence of the anesthetic gas dichloromethane (DCM). O UNTREATED 100 a Dсм 23 Torr Symbols: в Dсм 50 Torr x DCM I00 Torr o, 0 Torr DCM; O, 23 Torr DCM A, 50 Torr DCM x, 100 Torr DCM. 80 60 40 (1 Torr = 1 mm Hg.) 20 The solutions were buffered to pH 7.4. 0.5 1.0 1.5 2.0 log p02 (a) (* Hill plots. Label the axes and indicate on both the plot above and the Hill plot where the value of the dissociation equilibrium constant Ka for O2 binding is defined for 0 and 100 Torr of dichloromethane For the curves at 0 and 100 Torr of dichloromethane, draw their equivalent in the form of Kd Hb(O2)n Hb + nO2 % OXYGENATION
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