Penicillin heralded the dawn of the antibiotic age when it was discovered in 1928 and is now the most widely used antibiotic in the world. A membrane electrode was developed for the quantitative analysis of penicillin. The table above shows the data which were collected using a set of penicillin standards against saturated calomel electrode. An unknown sample produced a potential of 142 mV. A) Which served as the reference electrode? B) What is the molar concentration of penicillin in the sample?
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Penicillin heralded the dawn of the antibiotic age when it was discovered in 1928 and is now the most widely used antibiotic in the world. A membrane electrode was developed for the quantitative analysis of penicillin. The table above shows the data which were collected using a set of penicillin standards against saturated calomel electrode. An unknown sample produced a potential of 142 mV.
A) Which served as the reference electrode?
B) What is the molar concentration of penicillin in the sample?
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- The order is for Ceftin 0.25 gPO, bid. On hand you have Ceftin 125mg tablets. How many tablets should you give?Your 67 YO 195lb, 5ft 10in male patient diagnosed with testicular cancer has been prescribed ifosfamide 1200mg/M2/day IV for 5 days. You calculate the BSA using the mosteller method as being 2.09m2. Ifosfamide is available in 60mL vials contianing 3g of drug. a) How many mL will you administer each day?Using conversion factors, solve each of the following clinicalproblems:a. A nurse practitioner prepares an injection of promethazine,an antihistamine used to treat allergic rhinitis. If thestock bottle is labeled 25 mg /mL and the order is a doseof 12.5 mg, how many milliliters will the nurse draw up inthe syringe?b. You are to give ampicillin 25 mg/kg to a child with a massof 62 lb. If stock on hand is 250 mg /capsule, how manycapsules should be given?
- Calculate, or make a best estimate of, the unknown factors in the situations listed in Table 1. Table 1. Data for problem 1. To find Data (i) Ek [K+]out = 4 mM; [K+]in = 130 mM (ii) [Cl-]in [Cl-]out = 570 mM; ECl = -65 mV (iii) ECl [Cl-]out = 150 mM; [Cl-]in = 8 mM; in a mammal (iv) [Na+]in Overshoot of action potential = +35 mV; saline [Na+] = 112 mM (v) [K+]in Blood [K+] = 3.2 mM; undershoot of action potential = -87 mV (vi) ECa [Ca2+]out = 5.6 mM; free [Ca2+]in = 0.8 mM (vii) [K+]out [K+]in = 350 mM; Ek = -82 mVHow much active ingredient in 20 cc of a 15% solution? You have 1:1000 concentration of epinephrine. How many mLs do you need to draw up if you want to give 45 mg of the drug? (I need help please :)Your 64YO 152lb, 5ft 8in female patient daignosed with advanced bladder cancerhas been prescribed ifosamide 1500mg/m2/day IV for 5 days. You calculate the BSA using the Mosteller method as being 1.82m2. Ifosfamide is available in 60mL vials containing 3g of drugs. How many mL will you administer each day?
- Which of the following is incorrect about blood glucose test interpretation A) fasting plasma glucose 6.1-6.8 defined as having IGT and should probably be screened again after a year or so. B) 2 results>7mmmol/l defined as having diabetes C) fasting plasma glucose >6mmol, recall for further test. D) fasting or random plasma glucose, on one reading of <11.1mmol/l is diagnostic of diabetesAcetaminophen Elixir 120 mg/5 mL During the Covid-19 epidemic, the public were advised high fever was a common side effect of infection and to ensure they had acetaminophen on hand. Because of this, there was a sudden nation-wide shortage of commercial liquid acetaminophen. The local Doctor asked if you could compound a mixture for a young child with otitis media as the Mother cannot find any commercially. The Pharmacist did some research and found the following referenced formula for you to use. The Doctor would like to give 50 mL. The child weighs 16 kg. Formulation: Acetaminophen 120 mg 90% ethanol 0.7 mL Propylene glycol 0.5 mL Purified water 0.5 mL Glycerol qs ad 5 mL Dissolve acetaminophen in ethanol and propylene glycol, add most of the glycerol, add water, adjust to volume with glycerol. Strength: 120 mg/5 mL Child dose: 15 mg/kg q4-6h. Maximum 4 doses in 24 hours. Warnings: Contains 13% alcohol EUD: As per local guidelines. Questions: Calculate appropriate…1000 Tablets 48, Kandivli Ind Estate, Mumbai 400 067, India by: Ipca Laboratories Limited Jacksonville, FL 32257 USA Ranbaxy Pharmaceuticals Inc. Manufactured for Rx only LOT: EXP: 100 mg TABLETS, USP ALLOPURINOL N Each scored tablet contains: Allopurinol, USP........100 mg Store at 20° to 25°C (68° to 77° F) [See USP Controlled Room Temperature]. Dispense in tight, light-resistant container as defined in the USP. USUAL DOSE: One tablet daily. For indications, dosage, precautions, etc., see accompanying package insert. Code: DNH/DRUGS/NH/170 3 633041153910 NDC 63304-539-10 Non varnish area R RANBAXY LBZTL6 0311 Expiration date Prescription warning Total amount in vial, packet, box Usual adult dose Dosage strength Drug form Lot number (control number) National Drug Code (N D C) # Manufacturer Brand name Generic name
- Accelerated Stability Testing Data Determine the expiration date of a drug product with the initial drug concentration of 50 mg/tablet using the following accelerated stability testing data: log Temp Rate Constant (1/min) 1/T (oC) 70 1.73E-05 80 3.38E-05 90 6.45E-05 Reaction Kinetics - Accelerated Stability Testing log In k Rate Constant Temp (oC) Temp (к) (1/min) (1/K) k 70 1.73E-05 80 3.38E-05 90 6.45E-05The prescription requires 15 1g suppositories, containing 50mg of the drug to be produced. You prepare 20 suppositories. The displacement value of the drug is 1.5.How much base is required? (Give your answer to one decimal place) The following equation can be used:Amount of base required = theoretical amount – displaced amountWhere; Displaced amount = (amount of drug in g/DV of drug). unuit:gAvailable cloxacillin 2g match the following reconstitution option with the order ordered: 1500 mg of cloxacillin IV q8h ordered: 800 mg of cloaxacillin IM q6h ordered: 500 mg of cloxacillin IM q8h ordered: 1800 mg of cloxacillin IV q8h 1. 2. add 4.8 mL sterile water for concentration of 400mg/mL add 9.8 mL of sterile water for concentration of 200 mg/mL