Homework Help is Here – Start Your Trial Now!
Science
Biochemistry
Starting from the O2 binding equilibrium of human hemoglobin written below, derive the Hb + nO2 2 Hb(O2)n underlying the Hill plot. Draw a generic Hill plot and indicate at what O2 saturation conditions rium dissociation constants (Kd, K1, K4) are defined by the plot. Also, show how the values coefficient are determined at 50% saturation and at their asymptotic limits. Explain the ion of the value of the Hill coefficient nH at 50% saturation compared to the total number of

Starting from the O2 binding equilibrium of human hemoglobin written below, derive the Hb + nO2 2 Hb(O2)n underlying the Hill plot. Draw a generic Hill plot and indicate at what O2 saturation conditions rium dissociation constants (Kd, K1, K4) are defined by the plot. Also, show how the values coefficient are determined at 50% saturation and at their asymptotic limits. Explain the ion of the value of the Hill coefficient nH at 50% saturation compared to the total number of

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
See similar textbooks
icon
Related questions
Question
1. Starting from the O2 binding equilibrium of human hemoglobin written below, derive the Hb nO2 2 Hb(O2)n + equation underlying the Hill plot. Draw a generic Hill plot and indicate at what O2 saturation conditions the equilibrium dissociation constants (Kd, K1, K4) are defined by the plot. Also, show how the values of the Hill coefficient are determined at 50% saturation and at their asymptotic limits. Explain the interpretation of the value of the Hill coefficient nH at 50% saturation compared to the total number of subunits in the allosteric molecule.
Transcribed Image Text:1. Starting from the O2 binding equilibrium of human hemoglobin written below, derive the Hb nO2 2 Hb(O2)n + equation underlying the Hill plot. Draw a generic Hill plot and indicate at what O2 saturation conditions the equilibrium dissociation constants (Kd, K1, K4) are defined by the plot. Also, show how the values of the Hill coefficient are determined at 50% saturation and at their asymptotic limits. Explain the interpretation of the value of the Hill coefficient nH at 50% saturation compared to the total number of subunits in the allosteric molecule.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 3 steps with 1 images

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON
SEE MORE TEXTBOOKS