Determine the expiration date of a drug product with the initial drug concentration of 50 mg/tablet using the following accelerated stability testing data: Accelerated Stability Testing Data Temp (oC) Rate Constant (l/min) 70 1.73E-05 80 3.38E-05 90 6.45E-05 Reaction Kinetics- Accelerated Stability Testing Temp (oC) 70 8.0 Temp (K) Rate Constant (l/min) 1/T 1.73E-05 3.38E-05 1/T (1/K) log k In k log k
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- Drug A has the concentrations indicated below in the blood following intravenous administration. From these data calculate the half-life (t1/2) of Drug A is: Drug A Concentrations Time After Intravenous Administration μg/mL of drug A in blood 2 hours 100 6 hours 25 10 hours 6.25 14 hours 1.56If a patient weighing 175 lb is to receive an initial daily IM dosage of procainamide HCI (500 mg/mL vial) of 50 mg/kg to be given in divided doses every 3 hours. How many milliliters should each injection contain? O a. 3.98 mL O b. 8.23 mL O C. 0.49 mL O d. 0.99 mL O e. 1.87 mLIdentify the binding interactions that might be possible for the drug reported below. Rank these interactions by increasing energy.
- Digitalis, a drug used to control atrial fibrillation in patients is to be delivered to have a the drug amount to 20.0 μμg/kg body weight (2.205 pounds = 1.00 kg). The drug concentration must be carefully controlled and accurately measured or the patient may die from too low of concentration from heart complications or too high concentrations of fatal overdose. Calculate the mL of digitalis needed to treat a 160.0 pound patient using 0.800 mg/mL digitalis solution.3a) An 68 kg patient is to be given a 2.0 mg/kg body weight IV bolus dose of a newly developed antibiotic drug every 6 hours. Assume the half-life of the drug and its volume of distribution in the patient are 3.2 hours and 0.26 L/kg respectively. (a) Calculate the peak and trough plasma concentrations for the antibiotic after, one dose, two doses, four doses, and at steady state.Please show dimensional analysis to solve
- Dosage Calculations Calculate the following dosages. What volume of PCN G is in one dose? Ordered: PCN G 1.25 mil units Available: Multidose vial labeled 500,000 units/mL after reconstitutionAnswer the questions based on the data table. [s] mM 0.333 0.40 0.50 0.666 1.0 2.0 V (M/s) Uninhibited 1.65 x 107 1.86 x 107 2.13 x 107 2.49 x 107 2.99 x 107 3.72 x 107 V (M/s) x 107 Inhibitor A 1.05 x 107 1.21 x 107 1.43 x 107 1.74 x 107 2.22 x 107 3.08 x 107 Determine the Km and Vmax of the enzyme. Determine the type of inhibition imposed by inhibitor A. Determine the type of inhibition imposed by inhibitor B. V (M/s) x 107 Inhibitor B 0.794 x 107 0.893 x 107 1.02 x 107 1.19 x 107 1.43 x 107 1.79 x 107A pharmacist is preparing a compounded oral suspension preparation using commercially available tablets as the source of the active pharmaceutical ingredient (API). The recipe is as follows: "API" 0.8 mg/mL Structured suspension vehicle qs ad 180 mL Sig: 2 tsp PO BID PRN The tablets are available at a strength of 25 mg. Assume that when the the minimum number of tablets is used to prepare this compounded suspension, the crushed tablets take up 9.5 mL of volume.What volume of suspension structured vehicle will be needed to prepare this compounded oral solution?Round the answer to one decimal place.
- If a powder in a 2gm vial diluted with 6.8ml of diluent provides 8ml of solution and each ml contains 250mg of a drug, how many ml is needed to give 750mg.25. ATROVENT Nasal Spray contains 0.03% of ipratropium bromide in a 30-mL me- tered dose container. If the container is calibrated to deliver 345 sprays, calculate the volume of each spray, in microliters, and the medication content of each spray, in micrograms. 25. 86.96 µL /spray and 26.09 µg ipra- tropiumA pharmacist is preparing a compounded oral suspension preparation using commercially available tablets as the source of the active pharmaceutical ingredient (API). The recipe is as follows: "API" 0.8 mg/mL Structured suspension vehicle qs ad 240 mL Sig: 1 tsp PO BID PRN The tablets are available at a strength of 20 mg. Assume that when the the minimum number of tablets is used to prepare this compounded suspension, the crushed tablets take up 12.2 mL of volume.What volume of suspension structured vehicle will be needed to prepare this compounded oral solution?Round the answer to one decimal place.