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You are a doctor and one of your patients is presenting symptoms of beriberi. Beriberi is a nutritional deficiency disorder that causes horrible neurologic symptoms.   You measured a few metabolites in the blood of this patient and found that they have high levels of pyruvate (this is after eating a high-carbohydrate meal). Why?   This patient loves their fish, and their diet is mostly fish (which contains the enzyme thiaminase). After experimenting with different ways of eating their fish, they’ve found that if they have cooked the fish, they don’t have symptoms of this disease; however, if they eat the fish raw, they continue having symptoms. Why do you think this happens?

You are a doctor and one of your patients is presenting symptoms of beriberi. Beriberi is a nutritional deficiency disorder that causes horrible neurologic symptoms.   You measured a few metabolites in the blood of this patient and found that they have high levels of pyruvate (this is after eating a high-carbohydrate meal). Why?   This patient loves their fish, and their diet is mostly fish (which contains the enzyme thiaminase). After experimenting with different ways of eating their fish, they’ve found that if they have cooked the fish, they don’t have symptoms of this disease; however, if they eat the fish raw, they continue having symptoms. Why do you think this happens?

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You are a doctor and one of your patients is presenting symptoms of beriberi. Beriberi is a nutritional deficiency disorder that causes horrible neurologic symptoms.  

  1. You measured a few metabolites in the blood of this patient and found that they have high levels of pyruvate (this is after eating a high-carbohydrate meal). Why?  
  2. This patient loves their fish, and their diet is mostly fish (which contains the enzyme thiaminase). After experimenting with different ways of eating their fish, they’ve found that if they have cooked the fish, they don’t have symptoms of this disease; however, if they eat the fish raw, they continue having symptoms. Why do you think this happens?
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