Substrate 1 Site A Nonpolar Polar and neutral Polar and Site D Site B Polar and neutral Acidic (negatively charged) Basic (positively Site C Polar and neutral Basic (positively charged) 2 Nonpolar

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Enzymes are catalytic proteins or RNA molecules that accelerate chemical reactions. Substrates 
are the molecules that are acted upon by enzymes and are converted into products through the 
binding of substrates to an enzyme’s active site. Figure 1 below shows a protein enzyme’s active 
site and four potential protein substrates. Table 1 indicates the different chemical properties at 
several locations in a hypothetical enzyme’s active site, and Table 2 indicates the different 
chemical properties at several locations in the potential substrates. Locations labeled “A” in the 
enzyme’s active site and on the substrate will attempt to interact, as will locations that are labeled 
“B” and “C.

Describe, in terms of energy, how enzymes catalyze chemical reactions. 

 

 

Site B
Polar and neutral
Acidic (negatively
charged)
Basic (positively
charged)
Acidic (negatively
charged)
Site C
Substrate
1
Site D
X
Site A
Nonpolar
Polar and
Polar and neutral
Basic (positively
charged)
2
Nonpolar
neutral
Polar and
3
Polar and neutral
X
neutral
Polar and
neutral
4
Nonpolar
Table 2. Substrate location chemical properties
Transcribed Image Text:Site B Polar and neutral Acidic (negatively charged) Basic (positively charged) Acidic (negatively charged) Site C Substrate 1 Site D X Site A Nonpolar Polar and Polar and neutral Basic (positively charged) 2 Nonpolar neutral Polar and 3 Polar and neutral X neutral Polar and neutral 4 Nonpolar Table 2. Substrate location chemical properties
Enzyme
Substrates
B
Figure 1. Enzyme and potential substrates
Chemical Property
Polar and neutral
Acidic (negatively charged)
Nonpolar
Table 1. Enzyme active site properties
Site
A
B
Transcribed Image Text:Enzyme Substrates B Figure 1. Enzyme and potential substrates Chemical Property Polar and neutral Acidic (negatively charged) Nonpolar Table 1. Enzyme active site properties Site A B
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