Enzymes are catalytic proteins or RNA molecules that accelerate chemical reactions. Substrates  are the molecules that are acted upon by enzymes and are converted into products through the  binding of substrates to an enzyme’s active site. Figure 1 below shows a protein enzyme’s active  site and four potential protein substrates. Table 1 indicates the different chemical properties at  several locations in a hypothetical enzyme’s active site, and Table 2 indicates the different  chemical properties at several locations in the potential substrates. Locations labeled “A” in the  enzyme’s active site and on the substrate will attempt to interact, as will locations that are labeled  “B” and “C. Based on Figure 1, explain whether the enzyme is more likely to bind with substrate 2 or  substrate 4.

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Enzymes are catalytic proteins or RNA molecules that accelerate chemical reactions. Substrates 
are the molecules that are acted upon by enzymes and are converted into products through the 
binding of substrates to an enzyme’s active site. Figure 1 below shows a protein enzyme’s active 
site and four potential protein substrates. Table 1 indicates the different chemical properties at 
several locations in a hypothetical enzyme’s active site, and Table 2 indicates the different 
chemical properties at several locations in the potential substrates. Locations labeled “A” in the 
enzyme’s active site and on the substrate will attempt to interact, as will locations that are labeled 
“B” and “C.

Based on Figure 1, explain whether the enzyme is more likely to bind with substrate 2 or 
substrate 4.

Enzyme
Substrates
B
Figure 1. Enzyme and potential substrates
Chemical Property
Polar and neutral
Acidic (negatively charged)
Nonpolar
Table 1. Enzyme active site properties
Site
A
B
Transcribed Image Text:Enzyme Substrates B Figure 1. Enzyme and potential substrates Chemical Property Polar and neutral Acidic (negatively charged) Nonpolar Table 1. Enzyme active site properties Site A B
Site B
Polar and neutral
Acidic (negatively
charged)
Basic (positively
charged)
Acidic (negatively
charged)
Site C
Substrate
1
Site D
X
Site A
Nonpolar
Polar and
Polar and neutral
Basic (positively
charged)
2
Nonpolar
neutral
Polar and
3
Polar and neutral
X
neutral
Polar and
neutral
4
Nonpolar
Table 2. Substrate location chemical properties
Transcribed Image Text:Site B Polar and neutral Acidic (negatively charged) Basic (positively charged) Acidic (negatively charged) Site C Substrate 1 Site D X Site A Nonpolar Polar and Polar and neutral Basic (positively charged) 2 Nonpolar neutral Polar and 3 Polar and neutral X neutral Polar and neutral 4 Nonpolar Table 2. Substrate location chemical properties
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