Part (a) Identify the key characteristics of click chemistry. Detail, using schematics, the use of ligand co-catalysts as an important proponent of the overall CuAAC mechanism. Part (b) (1) (ii) Parallel synthesis and combinatorial chemistry are two approaches to the development of drug libraries. Identify the key differences between the two and compare the advantages and disadvantages of both. The structure below is a part of an overall oligonucleotide generated through solid- phase synthesis. Identify the 3 sites that need to be protected during the SPS process and provide an example of a protecting group that can be used in each site. Choose any one of the protection groups and describe the deprotection mechanism.

Part (a) Identify the key characteristics of click chemistry. Detail, using schematics, the use of ligand co-catalysts as an important proponent of the overall CuAAC mechanism. Part (b) (1) (ii) Parallel synthesis and combinatorial chemistry are two approaches to the development of drug libraries. Identify the key differences between the two and compare the advantages and disadvantages of both. The structure below is a part of an overall oligonucleotide generated through solid- phase synthesis. Identify the 3 sites that need to be protected during the SPS process and provide an example of a protecting group that can be used in each site. Choose any one of the protection groups and describe the deprotection mechanism.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

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Question

Part (a)
Identify the key characteristics of click chemistry. Detail, using schematics, the use of
ligand co-catalysts as an important proponent of the overall CuAAC mechanism.
Part (b)
(1)
(ii)
Parallel synthesis and combinatorial chemistry are two approaches to the
development of drug libraries. Identify the key differences between the two and
compare the advantages and disadvantages of both.
The structure below is a part of an overall oligonucleotide generated through solid-
phase synthesis. Identify the 3 sites that need to be protected during the SPS
process and provide an example of a protecting group that can be used in each
site. Choose any one of the protection groups and describe the deprotection
mechanism.
0-P=0
Part (c)
Nusinersen is an ASO used for the treatment of spinal muscular atrophy (SMA). Using your
knowledge of antisense oligonucleotide development, identify the key aspects of the design
of this oligonucleotide. Suggest possible chemical modifications that can be introduced to
improve its targeting properties in cellular environments. Use schematics and provide
reasoning for all changes made.

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Step 2: Part (a) Click Chemistry and CuAAC Mechanism

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Step 3: Part (b) Parallel Synthesis vs. Combinatorial Chemistry

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Step 4: Part (c) Oligonucleotide Design and Modifications

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