**Histidine in Aqueous Solution**Now let’s consider histidine as a free amino acid in aqueous solution.a) **Structure of Histidine:**Draw the most likely structure of histidine under biochemical standard state conditions.b) **Assignment of pKₐ Values:**Given that free histidine has the following three pKₐ values, assign each to its corresponding acidic hydrogen or conjugate base in your structure from part a).- pKₐ₁ = 1.7- pKₐ₂ = 6.0- pKₐ₃ = 9.1c) **Equilibrium Expressions:**For each pKₐ, give the corresponding expression for the equilibrium constant. *It helps to write out the chemical equation for each.*

The structure of histidine at standard biochemical condition is given below It exist in its…

Now let's consider histidine as a free amino acid in aqueous solution. Draw the most likely structure of histidine under biochemical standard state conditions. Given that free histidine has the following three pK, values, assign each to its corresponding acidic hydrogen or conjugate base in your structure from part a). pK1 = 1.7, pK22 = 6.0, pK33 = 9.1 For each pKa, give the corresponding expression for the equilibrium constant.

Now let's consider histidine as a free amino acid in aqueous solution. Draw the most likely structure of histidine under biochemical standard state conditions. Given that free histidine has the following three pK, values, assign each to its corresponding acidic hydrogen or conjugate base in your structure from part a). pK1 = 1.7, pK22 = 6.0, pK33 = 9.1 For each pKa, give the corresponding expression for the equilibrium constant.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

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Question

**Histidine in Aqueous Solution**

Now let’s consider histidine as a free amino acid in aqueous solution.

a) **Structure of Histidine:**
Draw the most likely structure of histidine under biochemical standard state conditions.

b) **Assignment of pKₐ Values:**
Given that free histidine has the following three pKₐ values, assign each to its corresponding acidic hydrogen or conjugate base in your structure from part a).

- pKₐ₁ = 1.7
- pKₐ₂ = 6.0
- pKₐ₃ = 9.1

c) **Equilibrium Expressions:**
For each pKₐ, give the corresponding expression for the equilibrium constant. *It helps to write out the chemical equation for each.*

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