A difficult problem in the synthesis of PGF2α is the introduction of the OH group at C15 in the desired configuration. a. Label this stereogenic center as R or S. b. A well-known synthesis of PGF2α involves reaction of A with Zn(BH4)2, a metal hydride reagent similar in reactivity to NaBH4, to form two isomeric products, B and C. Draw their structures and indicate their stereochemical relationship. d. Suggest a reagent to convert A to the single stereoisomer X. ОНноноОНӧнхPGF24[1] Zn(BH4)2[2] Н,ОB and C

(a) Stereogenic center can be labeled

Answered: ОН но но ОН ӧн х PGF24 [1] Zn(BH4)2 [2]…

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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A difficult problem in the synthesis of PGF_2α is the introduction of the
OH group at C15 in the desired configuration.
a. Label this stereogenic center as R or S.
b. A well-known synthesis of PGF_2α involves reaction of A with Zn(BH₄)₂, a metal hydride reagent similar in reactivity to NaBH₄, to form two isomeric products, B and C. Draw their structures and indicate their stereochemical relationship.
d. Suggest a reagent to convert A to the single stereoisomer X.

ОН
но
но
ОН
ӧн
х
PGF24
[1] Zn(BH4)2
[2] Н,О
B and C

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