teases are enzymes that can break covalent bonds in proteins. Proteases play major roles in the regulation of biological processes, ompounds that inhibit their function, called protease inhibitors, have potential as therapeutic agents. While preparing several ential protease inhibitors, compound 1 was converted into compound 3 via alkyne 2, as shown. (J. Org. Chem. 1989, 54, 3963- 2) Draw the structure of alkyne 2, and propose reagents for converting 1 into 3. -p1 Br 2 alle--ell (~-10) Ph = Br Br Br Ph O Edit Drawing 1 OH OH O lodify the given structure of 1 to draw alkyne 2. An eraser is available, and you can use the single bond tool to add/remove pi onds. Ph 3 OH

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter18: Functional Derivatives Of Carboxylic Acids
Section18.8: Interconversion Of Functional Derivatives
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Proteases are enzymes that can break covalent bonds in proteins. Proteases play major roles in the regulation of biological processes,
so compounds that inhibit their function, called protease inhibitors, have potential as therapeutic agents. While preparing several
potential protease inhibitors, compound 1 was converted into compound 3 via alkyne 2, as shown. (J. Org. Chem. 1989, 54, 3963-
3972) Draw the structure of alkyne 2, and propose reagents for converting 1 into 3.
Step 1
Br
Br
Ph
alle
Br
Br
Edit Drawing
OH
Modify the given structure of 1 to draw alkyne 2. An eraser is available, and you can use the single bond tool to add/remove pi
bonds.
OH
2
Ph
O
ell (-10)
Ph =
3
OH
Transcribed Image Text:Proteases are enzymes that can break covalent bonds in proteins. Proteases play major roles in the regulation of biological processes, so compounds that inhibit their function, called protease inhibitors, have potential as therapeutic agents. While preparing several potential protease inhibitors, compound 1 was converted into compound 3 via alkyne 2, as shown. (J. Org. Chem. 1989, 54, 3963- 3972) Draw the structure of alkyne 2, and propose reagents for converting 1 into 3. Step 1 Br Br Ph alle Br Br Edit Drawing OH Modify the given structure of 1 to draw alkyne 2. An eraser is available, and you can use the single bond tool to add/remove pi bonds. OH 2 Ph O ell (-10) Ph = 3 OH
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