Gabapentin, an anticonvulsant used in the treatment of epilepsy, is structurally related to the neurotransmitter 4-aminobutanoic acid (GABA). -NH2 -NH, B -СООН COOH Gabapentin 4-Aminobutanoic acid (y-Aminobutyric acid, GABA) Gabapentin was designed specifically to be more lipophilic than GABA and therefore more likely to cross the blood-brain barrier, the lipidlike protective membrane that sur- rounds the capillary system in the brain and prevents hydrophilic (water-loving) com- pounds from entering the brain by passive diffusion. Given the following retrosynthetic analysis, propose a synthesis for gabapentin. -NH, -NH2 CN COOH -COOEt COOEt Gabapentin COOEt COOE. O + COOEt COOEt Cyclohexanone Diethyl malonate

Gabapentin, an anticonvulsant used in the treatment of epilepsy, is structurally related to the neurotransmitter 4-aminobutanoic acid (GABA). -NH2 -NH, B -СООН COOH Gabapentin 4-Aminobutanoic acid (y-Aminobutyric acid, GABA) Gabapentin was designed specifically to be more lipophilic than GABA and therefore more likely to cross the blood-brain barrier, the lipidlike protective membrane that sur- rounds the capillary system in the brain and prevents hydrophilic (water-loving) com- pounds from entering the brain by passive diffusion. Given the following retrosynthetic analysis, propose a synthesis for gabapentin. -NH, -NH2 CN COOH -COOEt COOEt Gabapentin COOEt COOE. O + COOEt COOEt Cyclohexanone Diethyl malonate

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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