Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Question
A difficult problem in the synthesis of PGF2α is the introduction of the OH group at C15 in the desired configuration.
a. Label this stereogenic center as R or S.
b. A well known synthesis of PGF2α involves reaction of A with Zn(BH4)2, a metal hydride reagent similar in reactivity to NaBH4, to form two isomeric products, B and C. Draw their structures and indicate their stereochemical relationship.
c. Suggest a reagent to convert A to the single stereoisomer X.
![ОН
он
Он
но
(1) Zn(BH,)2
(2] H20
PGF2
B and C](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F00e3b56e-fa54-4a18-9c6f-8593c3725527%2F165bce80-eb3f-45ee-8590-1a1061127ebd%2Fh1kfnvm.png&w=3840&q=75)
Transcribed Image Text:ОН
он
Он
но
(1) Zn(BH,)2
(2] H20
PGF2
B and C
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