2. Above is S-adenosylmethionine (SAM). Note that R'-S-R is a very good leaving group. You do not need to know anything else about sulfur to answer this question. a) SAM is famous for being a biological methylating agent. Draw a classical organic methylation reaction between [CH3-CH2-CH2-O] and CH3Br using the arrow formalism, clearly indicating the product. b) Among all of the elements in the above reaction, which has the greatest electronegativity? c) Write a rate law for this reaction: d[P]/dt = d) In the above rate law, what are the units of k? e) Examining the structure of SAM, you notice that three different carbon atoms are bound to sulfur. Circle these carbon atoms and label them (starting from the 12 o'clock position and
Reactive Intermediates
In chemistry, reactive intermediates are termed as short-lived, highly reactive atoms with high energy. They rapidly transform into stable particles during a chemical reaction. In specific cases, by means of matrix isolation and at low-temperature reactive intermediates can be isolated.
Hydride Shift
A hydride shift is a rearrangement of a hydrogen atom in a carbocation that occurs to make the molecule more stable. In organic chemistry, rearrangement of the carbocation is very easily seen. This rearrangement can be because of the movement of a carbocation to attain stability in the compound. Such structural reorganization movement is called a shift within molecules. After the shifting of carbocation over the different carbon then they form structural isomers of the previous existing molecule.
Vinylic Carbocation
A carbocation where the positive charge is on the alkene carbon is known as the vinyl carbocation or vinyl cation. The empirical formula for vinyl cation is C2H3+. In the vinyl carbocation, the positive charge is on the carbon atom with the double bond therefore it is sp hybridized. It is known to be a part of various reactions, for example, electrophilic addition of alkynes and solvolysis as well. It plays the role of a reactive intermediate in these reactions.
Cycloheptatrienyl Cation
It is an aromatic carbocation having a general formula, [C7 H7]+. It is also known as the aromatic tropylium ion. Its name is derived from the molecule tropine, which is a seven membered carbon atom ring. Cycloheptatriene or tropylidene was first synthesized from tropine.
Stability of Vinyl Carbocation
Carbocations are positively charged carbon atoms. It is also known as a carbonium ion.
f, g, h, i plz
![2. Above is S-adenosylmethionine (SAM). Note that R'-S-R is a very good leaving group. You do not need
to know anything else about sulfur to answer this question.
a) SAM is famous for being a biological methylating agent. Draw a classical organic methylation
reaction between [CH3-CH2-CH2-O] and CH3BR using the arrow formalism, clearly indicating
the product.
b) Among all of the elements in the above reaction, which has the greatest electronegativity?
c) Write a rate law for this reaction: d[P]/dt =
d) In the above rate law, what are the units of k?
e) Examining the structure of SAM, you notice that three different carbon atoms are bound to
sulfur. Circle these carbon atoms and label them (starting from the 12 o'clock position and
going clockwise) #1, #2, and #3. Which of these, if any, are chiral carbons?
f) From the perspective of nucleophilic substitution with R'-S-R as the leaving group, is carbon
#1 methyl, primary, secondary, or tertiary? Carbon #2? Carbon #3?
g) Which of these carbons can reasonably react with a nucleophile via the SN2 mechanism?
h) Which carbon is subject to nucleophilic attack when SAM is used as a methylating agent?
i) Is this the most intrinsically reactive of the three circled carbons to SN2 substitution? Briefly
(less than 6 words) justify your answer.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fa76acd85-1038-470b-93a5-cc8f3268b5fe%2F8aab8c89-ab77-4ac0-809e-8a4985cbcd06%2F4p9uhg_processed.png&w=3840&q=75)
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