Match the each enzyme deficiency with their corresponding disease β-hexosaminidase A α -galactosidase Sphigomyelinase β-glucosidaseA.Fabry diseaseB.Tay-Sachs diseaseC.Niemann-Pick diseaseD.Gaucher disease

Different enzymes are required for synthesis of spingolipids. If these enzymes are not…

Answered: Match the each enzyme deficiency with…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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You discover that rather than being hormonally regulated (as seen above in humans), hexose kinase is part of an operon in prokaryotic organisms. This operon is known as the "hexose operon" and it regulates expression of the complete set of enzymes needed to convert a hexose sugar into 2 pyruvate molecules. d. Remembering that hexose metabolism is a highly conserved process among all branches of life, how many genes do you expect to find in this operon? Explain your logic.
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define and explain unctions of Tra A, Tra D, Tra I, Ori T, relaxase
1.Sustaining intense exercise requires ATP. Could a someone with a defective gene for the enzyme lactate dehydrogenase meet the ATP demand for sustained and intense exercise? Why or why not? Be sure to support your argument with discussion of the metabolic pathways and tissues impacted. 2.Genetic carriers for metabolic diseases (persons heterozygous for a recessive mutation) produce about half the normal amount of the affected enzyme, but rarely exhibit any symptoms or effects. Rationalize this observation, based on your knowledge of the flux and regulation of metabolic pathways.
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Aromatase inhibitors are a new generation of drugs used to treatwomen who have estrogen-sensitive breast cancers (cancersthat grow most rapidly when estrogen is present). Explain whyaromatase inhibitors are useful in these cases.

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Match the each enzyme deficiency with their corresponding disease β-hexosaminidase A α -galactosidase Sphigomyelinase β-glucosidase A. Fabry disease B. Tay-Sachs disease C. Niemann-Pick disease D. Gaucher disease