Cytokinetics is a Bay Area pharmaceutical company that has developed a drug called Tirasemtiv for the treatmentof motor disorders including ALS (amyotrophic lateral sclerosis) and myasthenia gravis. Tirasemtiv acts on skeletal muscle troponin and increases its affinity for calcium. a. Recall the role of calcium in muscle contraction. Describe what would happen if you gave a control patient Tirasemtiv. Be sure to include what the effect would be and what you would want to measure to figure out the difference in activity before and after Tirasemtiv administration. b. In ALS, there is loss of upper and lower motor neurons. In myasthenia gravis, circulating antibodies block acetylcholine receptors on the muscle. Describe what motor deficits you would expect to see in patients with these diseases. c. Describe how you think Tirasemtiv would be useful in the treatment of ALS and myasthenia gravis.
3) Cytokinetics is a Bay Area pharmaceutical company that has developed a drug called Tirasemtiv for the treatmentof motor disorders including ALS (amyotrophic lateral sclerosis) and myasthenia gravis. Tirasemtiv acts on skeletal muscle troponin and increases its affinity for calcium.
a. Recall the role of calcium in muscle contraction. Describe what would happen if you gave a control patient
Tirasemtiv. Be sure to include what the effect would be and what you would want to measure to figure out
the difference in activity before and after Tirasemtiv administration.
b. In ALS, there is loss of upper and lower motor neurons. In myasthenia gravis, circulating antibodies
block acetylcholine receptors on the muscle. Describe what motor deficits you would expect to see in
patients with these diseases.
c. Describe how you think Tirasemtiv would be useful in the treatment of ALS and myasthenia gravis.
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