Question 2Which of the following is/are true with regard to the therapeutic index and the therapeutic windowof a drug (there may be more than one true statement)?Therapeutic index is defined as ED50/TD50.Drugs with a narrow therapeutic window are best suited for minor conditions like headache or musclepain.Therapeutic window is the dose range that maximizes efficacy at minimum toxicity.Drugs with a wide therapeutic window can be used to treat serious life-threatening diseases.All of the above are correct.

The therapeutic range is the range of doses for a drug in which it produces therapeutic effects with…

Answered: Which of the following is/are true with…

Principles Of Pharmacology Med Assist

6th Edition

ISBN:9781337512442

Author:RICE

Publisher:RICE

Chapter7: Drug Sources, Schedules, And Dosages

Section: Chapter Questions

Problem 15RQ

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A patient is receiving morphine sulfate intravenously via a patient controlled analgesia (PCA) pump. The concentration of the solution is 11 mg/mL and is being infused continuously around the clock at a rate of 0.1 mL/hr. The patient may also access a 2-mg bolus dose every hour for breakthrough pain if needed and they are currently using an average of 5 additional bolus doses per day. The patient is to be converted to fentanyl using the table below. But before using the table we must determine their morphine usage, so what is this patient's total daily dosage of IV morphine? TABLE 10.3 FENTANYL TRANSDERMAL DOSAGE CONVERSION GUIDELINES", b Current Analgesic Oral morphine IM/IV morphine Oral oxycodone Oral codeine Oral hydromorphone IV hydromorphone IM meperidine Oral methadone 60-134 10-22 30-67 150-447 8-17 1.5-3.4 75-165 20-44 Recommended fentanyl transdermal system dose Fentanyl transdermal system 25 mcg/h Daily Dosage (mg/day) 135-224 23-37 67.5-112 17.1-28 3.5-5.6 166-278 45-74…
I need help with (ALL) please, my teacher did not teach and im clueless on how to do. Write answer and how you got the answer please :) THANKS! 1. How much active ingredient in 20 cc of a 15% solution? 2. You have 1:1000 concentration of epinephrine. How many mLs do you need to draw up if you want to give 45 mg of the drug? 3. How many mg of an active ingredient are in 4 mL of a 0.4% solution? 4. How many mLs do you need to give to get 20 mg of a 350mg/20mL dose? 5. Albuterol syrup is available in 2mg/5 mL. How much do you take if 6 mg is ordered? 6. Promazine HCL comes as 500 mg/10 mL. How many milliliters are needed to give a 150 mg dose? 7. 4 mg of morphine sulfate is ordered. you have a vial with 10mg/mL. How many mLs do you need to deliver? 8. Albuterol syrup is available in a 2 mg/ 5 mL concentration. If a dose schedule of 0.1 mg/kg is used, how much syrup is needed for a 30 kg. child? 9. A pediatric dose of oxytetracycline of 100 mg is ordered. The dosage form is an…
Question 5. Considering the above information, which route of administration would you favor for these drugs, would they be used as treatments in humans? Justify your answer
QUESTION 1 A. Define equilibrium constant of a drug B. Discuss the relationship between the equilibrium constant, affinity, potency and the response of a drug C. Discuss four factors that may affect a drug response
Select ready-made drugs in different dosage forms from the variety of drugs and classify them according to all classification signs (Annex 1). Write down the results into table 1. Ready-made drugs classification results No Name of ready- made drug By the By the By the applica-tion toxicity By physical By dates of By state of and chemical expira-tion aggregation and pharmaco- logical activity method properties dosage form Example Norfloxacine Antimicro-bial For internal General list Require light- Solid (tablets) Storage period is 3 agent use protection years 1 2 3 4 5 Classification
a) Define EDso and TDso. Calculate the therapeutic index (TI) for each of the following drugs based on the dose-response curves provided. Comment on the safety of these two treatments. 100 80- 60- 40- 20- Drug 1 Therapeutic effect Toxic effect 100 200 300 400 500 600 700 Drug dose (mg) 100- Therapeutic effect 80- 60- 17 40- 20- 0- 10 20 Drug 2 40 Toxic effect 60 80 100 120 Drug dose (mg) 140
Question 3. What is the primary purpose of the Glasgow Coma Scale (GCS) in nursing assessment? a) Assessing pain levels b) Measuring blood pressure c) Evaluating neurological status d) Monitoring respiratory rate
BiDil® is indicated for the treatment of heart failure as an adjunct to standard therapy in self-identified black patients to improve survival, to prolong time to hospitalization for heart failure, and to improve patient-reported functional status. Question 1: What are the generic drugs used to create BiDil®? Discuss the indications for both generics and controversy regarding the use of these 2 generic drugs to create BiDil®?
Read the following scientific paper from J.K Aronson titled: Medication errors: what they are, how they happen, and how to avoid them QJM: An International Journal of Medicine, Volume 102, Issue 8, August 2009, Pages 513– 521, https://doi.org/10.1093/qjmed/hcp052 Focus on the following sections: Abstract One particular medication error Frequency and outcomes of medication errors Conclusion: a prescription for better prescribing Once you have done the reading: Prepare a 150-200 words reflection piece on the importance of Topic 1 measurements for future health care professionals as you. Base your reflection on the resources provided. Drug Dosage and Body mass Medication errors: what they are, how they happen, and how to avoid them) You are most welcome to do quick research on measurement errors in your desired field of practice too (Pharmacy, Paramedic, Nutrition, Health Science, Exercise Science, Physiotherapy etc). To help you out here are some questions to answer in your…
rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1
Answer the following questions:1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product?2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product?3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)?4. How could the manufacturing process affect drug product performance?5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived?6. What is meant by “sink” conditions?7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration?8. For a lipid-soluble drug that has very poor aqueous solubility, what…
What is meant by a therapeutic window of a drug? b. Is it beneficial for a drug to have a wide or narrow therapeutic window? Motivate your answer

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