Naloxone is sometimes added to PO phenanthrene formulations to reduce injection abuse while retaining pain relief when used properly. Naltrexone is not used in this way because naltrexone:
1. is orally bioavailable
2. will reduce conversion of the opioid pro-drug
3. will cross the blood brain barrier.
4. has a longer half-life
5. should only be used for opioid maintenance therapy
The correct answer is 2 will reduce conversion of the opioid pro-drug.
Naltrexone is an opioid antagonist, meaning that it blocks the effects of opioids. This is why it is used to treat opioid use disorder. It is also why naltrexone would reduce the conversion of an opioid pro-drug, since opioid pro-drugs are converted into active opioids in the body.
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