Two of the most commonly used NSAIDS are ibuprofen and naproxen. Although they are both classified as "non-selective," they do have significant pharmacological differences.
NSAID COX-2 COX-1
Ibuprofen 15 1
Naproxen 1.3 2.2
1. irreversible inhibition of Cox-1
2. increased bleeding
3. reduced joint inflammation
Ibuprofen and naproxen are both non-selective NSAIDs, meaning they inhibit both COX-1 and COX-2 enzymes, but they have differences in their COX-1 and COX-2 selectivity, which can lead to varying effects:
Irreversible inhibition of COX-1: While both drugs inhibit COX-1, ibuprofen is known for its stronger and more sustained inhibition of COX-1, which can increase the risk of gastrointestinal side effects.
Increased bleeding: Ibuprofen, due to its stronger COX-1 inhibition, can increase the risk of bleeding disorders or gastric ulcers compared to naproxen. COX-1-derived prostaglandins play a role in platelet aggregation and clot formation. By inhibiting COX-1, ibuprofen can lead to a decreased ability of blood to clot, potentially resulting in an increased risk of bleeding events.
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