a) Define EDso and TDso. Calculate the therapeutic index (TI) for each of the following drugs based on the dose-response curves provided. Comment on the safety of these two treatments. Drug 1 Toxic effect 80- 60- VZXIZ 40- 20- 100 80- 60- 40- 20- 0 Therapeutic effect HILM 100 200 300 400 500 600 700 Drug dose (mg) 100- 0- 0 20 Drug 2 Therapeutic effect Toxic effect 40 60 80 100 120 140 Drug dose (mg)
a) Define EDso and TDso. Calculate the therapeutic index (TI) for each of the following drugs based on the dose-response curves provided. Comment on the safety of these two treatments. Drug 1 Toxic effect 80- 60- VZXIZ 40- 20- 100 80- 60- 40- 20- 0 Therapeutic effect HILM 100 200 300 400 500 600 700 Drug dose (mg) 100- 0- 0 20 Drug 2 Therapeutic effect Toxic effect 40 60 80 100 120 140 Drug dose (mg)
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Transcribed Image Text:a) Define EDso and TDso. Calculate the therapeutic index (TI) for each of the following drugs
based on the dose-response curves provided. Comment on the safety of these two
treatments.
100
80-
60-
40-
20-
Drug 1
Therapeutic
effect
Toxic
effect
100 200 300 400 500 600 700
Drug dose (mg)
100-
Therapeutic
effect
80-
60-
17
40-
20-
0-
10
20
Drug 2
40
Toxic
effect
60 80 100 120
Drug dose (mg)
140
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