Link: https://doi.org/10.1186/s12868-022-00692-1 A. In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “In Fig. 4, the demyelination of (A-C) the cerebellum and (F-H) brain stem was evaluated using LFB staining and median scored 2.5 in both sedentary and exercised untreated EAE rats indicating extensive demyelination.” Why was demyelination evaluated in this study? B. In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “Post-administration of mitoxantrone to sedentary and exercised groups smaller patches of demyelination with microcyst formation and lymphocytic infiltrates were seen; and bare unmyelinated axons were fewer (Figs. 3D, E, I, J and 4D, E, I, J).” Based on this quote, what is mitoxantrone doing exactly/directly?
Link: https://doi.org/10.1186/s12868-022-00692-1
A. In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “In Fig. 4, the demyelination of (A-C) the cerebellum and (F-H) brain stem was evaluated using LFB staining and median scored 2.5 in both sedentary and exercised untreated EAE rats indicating extensive demyelination.” Why was demyelination evaluated in this study?
B. In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “Post-administration of mitoxantrone to sedentary and exercised groups smaller patches of demyelination with microcyst formation and lymphocytic infiltrates were seen; and bare unmyelinated axons were fewer (Figs. 3D, E, I, J and 4D, E, I, J).” Based on this quote, what is mitoxantrone doing exactly/directly?
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