L-ornithine 2 carbamoylphosphate 3 L-citrulline 4 argininosuccinate 5 fumarato 6 L-arginine 7 urea L-Asp L-aspartate CPS-1 carbamoyl phosphate synthetase OTC Omnithine transcarbamoylase ASS argininosuccinate synthetase ASL argininosuccinate lyase ARG1 arginase 1 OH NH₂ H₂N NH CHI ASL CH₂ Coo CH₂ CH₂ coo Which of the reactions is requires energy input? (Answer by choosing the enzyme used)? 2ATPHCONH₂ 2 ADP. PCPS-1 H₂N ARG1 H₂O отс fessels - -8-5-9-8- CH₂ ASS H.M.000 ATP PP, L-Asp AMP
L-ornithine 2 carbamoylphosphate 3 L-citrulline 4 argininosuccinate 5 fumarato 6 L-arginine 7 urea L-Asp L-aspartate CPS-1 carbamoyl phosphate synthetase OTC Omnithine transcarbamoylase ASS argininosuccinate synthetase ASL argininosuccinate lyase ARG1 arginase 1 OH NH₂ H₂N NH CHI ASL CH₂ Coo CH₂ CH₂ coo Which of the reactions is requires energy input? (Answer by choosing the enzyme used)? 2ATPHCONH₂ 2 ADP. PCPS-1 H₂N ARG1 H₂O отс fessels - -8-5-9-8- CH₂ ASS H.M.000 ATP PP, L-Asp AMP
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question

Transcribed Image Text:**Educational Content: Urea Cycle Reactions**
The diagram illustrates the urea cycle, a crucial metabolic pathway for the detoxification of ammonia in the liver. The cycle involves a series of biochemical reactions that convert toxic ammonia to urea, which is excreted from the body.
### Key Components and Steps in the Urea Cycle:
1. **L-ornithine to carbamoyl phosphate**
- Enzyme: Carbamoyl phosphate synthetase I (CPS-I)
- Reactants: 2 ATP, HCO₃⁻, NH₄⁺
- Products: 2 ADP, P_i, Carbamoyl phosphate
2. **Ornithine transcarbamylase (OTC) reaction**
- Enzyme: Ornithine transcarbamylase (OTC)
- Substrate: Carbamoyl phosphate
- Product: Citrulline
- Transport: Citrulline is transported out of the mitochondria
3. **Argininosuccinate synthetase (ASS) reaction**
- Enzyme: Argininosuccinate synthetase (ASS)
- Reactants: Citrulline, Aspartate, ATP
- Products: Argininosuccinate, AMP, PP_i
4. **Argininosuccinate lyase (ASL) reaction**
- Enzyme: Argininosuccinate lyase (ASL)
- Product: Arginine, Fumarate
5. **Arginase 1 (ARG1) reaction**
- Enzyme: Arginase 1 (ARG1)
- Product: Urea, Ornithine
- Ornithine is then recycled back into the mitochondria for another cycle.
### Graphical Explanation:
- The left part of the diagram represents the mitochondrial membrane.
- The reactions within the membrane illustrate the synthesis of citrulline inside the mitochondria.
- The extra-mitochondrial reactions show the conversion of citrulline through subsequent steps eventually leading to urea.
- Each enzyme catalyzing a specific reaction is denoted next to the reaction step.
### Question:
Identify which of the reactions require energy input (Answer by choosing the enzyme used):
- OTC
- ASS
- ASL
- ARG1
- NONE of these require energy to do their reaction
The answer involves
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