Match the following antibiotics with the drug strategy that would provide resistance to them. rifampin which blocks transcription [Choose] [Choose ] tetracycline which misaligns the beta-lactamase anticodon to its codon mutation of the TRNA binding site of the ribosome penicillin which blocks peptidoglycan creation of alternate metabolic pathway that ultimately leads to the same product synthesis mutation of RNA polymerase polymyxin which causes leakage in the porin which removes drug from periplasmic space cell membrane sulfonamide which inhibits enzyme of [Choose ] folic acid synthesis pathway Question 14 2 pts 7 8 de 5
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
![Match the following antibiotics with the drug strategy that would provide resistance to
them.
rifampin which blocks transcription
[ Choose ]
Choose]
tetracycline which misaligns the
beta-lactamase
anticodon to its codon
mutation of the TRNA binding site of the ribosome
penicillin which blocks peptidoglycan
creation of alternate metabolic pathway that ultimately leads to the same product
synthesis
mutation of RNA polymerase
polymyxin which causes leakage in the
porin which removes drug from periplasmic space
cell membrane
sulfonamide which inhibits enzyme of
[Choose ]
folic acid synthesis pathway
Question 14
2 pts
%
&
5
7](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fa0009572-d30a-48fa-9e14-4e4f97407fb0%2F9b8a51fe-6bef-4d54-a239-c019cd742bf3%2F2wv10xl_processed.jpeg&w=3840&q=75)
Rifampicin -mutation of the RNA POLYMERASE
Rifamycin inihibts neither the binding of RNA polymerase to the promoter nor the formation of the first phosphodiester bonds , but they prevent further chain elongation. The inactivated RNA POLYMERASE remains bound to the promoter, therby blocking initiation by the unihibitex enzyme . The rifampicin binds to the exit channel of the RNA polymerase, therby inhibiting the further transcription .
Tetracycline-mutation of the tRNA binding site of the ribosome.
Tetracycline blocks the stringent response . Its indicated by the blockage of binding of deacylated tRNA to the A site
Pencillin -Beta lactamase
Pencillin specifically binds to and inactivates enzymes that crosslink the peptidoglycan strands of the bacterial cell walls . Pencillin contains a thiazollidine ring fused to a beta lactam ring
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