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The following are known substrates for ALP (Alkaline Phosphotase); nucleotide tri, di and monophosphate, deoxynucleotides, phosphoglycerate, 2-naphthyl phosphate, 4-nitrophenyl phosphate, cysteamine S-phosphate, fructose-6-phosphate, fructose-1-phosphate, glucose-6-phosphate, phosphoserine, phosphothreonine, pyridoxyl phosphate, pyrophosphate. From looking at the structure can you offer an explanation for how ALP can accommodate such different substrates?

The following are known substrates for ALP (Alkaline Phosphotase); nucleotide tri, di and monophosphate, deoxynucleotides, phosphoglycerate, 2-naphthyl phosphate, 4-nitrophenyl phosphate, cysteamine S-phosphate, fructose-6-phosphate, fructose-1-phosphate, glucose-6-phosphate, phosphoserine, phosphothreonine, pyridoxyl phosphate, pyrophosphate. From looking at the structure can you offer an explanation for how ALP can accommodate such different substrates?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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The following are known substrates for ALP (Alkaline Phosphotase); nucleotide tri, di and monophosphate, deoxynucleotides, phosphoglycerate, 2-naphthyl phosphate, 4-nitrophenyl phosphate, cysteamine S-phosphate, fructose-6-phosphate, fructose-1-phosphate, glucose-6-phosphate, phosphoserine, phosphothreonine, pyridoxyl phosphate, pyrophosphate. From looking at the structure can you offer an explanation for how ALP can accommodate such different substrates?

The image shows a three-dimensional representation of a protein structure using surface rendering. The protein is depicted in green, highlighting its complex shape and topology. This surface model illustrates the overall form of the protein, useful for understanding interactions with other molecules. There are also small red spheres within the protein structure, indicating the position of specific sites, such as active or binding sites, important for the protein's function. These highlighted areas help in identifying where biochemical interactions or reactions may occur. This type of visualization is commonly used in structural biology to study protein-ligand interactions, enzyme activity, and to design drugs that can bind to these sites effectively.
Transcribed Image Text:The image shows a three-dimensional representation of a protein structure using surface rendering. The protein is depicted in green, highlighting its complex shape and topology. This surface model illustrates the overall form of the protein, useful for understanding interactions with other molecules. There are also small red spheres within the protein structure, indicating the position of specific sites, such as active or binding sites, important for the protein's function. These highlighted areas help in identifying where biochemical interactions or reactions may occur. This type of visualization is commonly used in structural biology to study protein-ligand interactions, enzyme activity, and to design drugs that can bind to these sites effectively.
The image features a structural model of a protein. The structure is composed of several alpha helices and beta sheets, which are common elements in protein secondary structures. The protein is depicted in green, using a ribbon diagram representation, which helps in visualizing the folding and organization of the protein structure. In the image, there are distinct red spheres embedded within the structure. These spheres are likely to represent specific atoms or groups of atoms that play an important role in the protein's function, such as a substrate, cofactor, or part of an active site. Protein structural models like this are crucial for understanding the biological function of proteins, as the 3D shape of a protein is intimately connected with its role in cellular processes. This particular visualization allows for insights into how a protein might interact with other molecules, undergo conformational changes, or facilitate biochemical reactions. Such models are typically generated from data obtained through methods like X-ray crystallography or NMR spectroscopy, which provide atomic-level details of the protein's structure. Understanding these structures can aid in drug design, elucidation of metabolic pathways, and advancement of biotechnological applications.
Transcribed Image Text:The image features a structural model of a protein. The structure is composed of several alpha helices and beta sheets, which are common elements in protein secondary structures. The protein is depicted in green, using a ribbon diagram representation, which helps in visualizing the folding and organization of the protein structure. In the image, there are distinct red spheres embedded within the structure. These spheres are likely to represent specific atoms or groups of atoms that play an important role in the protein's function, such as a substrate, cofactor, or part of an active site. Protein structural models like this are crucial for understanding the biological function of proteins, as the 3D shape of a protein is intimately connected with its role in cellular processes. This particular visualization allows for insights into how a protein might interact with other molecules, undergo conformational changes, or facilitate biochemical reactions. Such models are typically generated from data obtained through methods like X-ray crystallography or NMR spectroscopy, which provide atomic-level details of the protein's structure. Understanding these structures can aid in drug design, elucidation of metabolic pathways, and advancement of biotechnological applications.
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