It 1. Morphine (below) is a natural product isolated from interacts with the µ opioid receptor (MOR) in the central nervous system as an agonist. What does it mean to be an agonist?

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Chapter1: Biochemistry: An Evolving Science
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1. Morphine (below) is a natural product isolated from.
interacts with the µ opioid receptor (MOR) in the central nervous system as an agonist. What does it
mean to be an agonist?
It
2. Morphine can be converted to Heroin (below) by treatment with X - put the reagent in the box
below.
но.
H3C
N-CH3
N--CH3
HO
H3C
morphine
heroin
Heroin is a pro-drug of morphine, which is more rapidly taken up into the brain than morphine, but
once inside of the brain converts to morphine due to esterase enzymes.
3. Provide the mechanism for the conversion of heroin to morphine below using hydroxide. You only
need to show the mechanism for the hydrolysis of one of the esters.
H3C.
но.
NaOH
„N~CH, H20
N--CHs
HO
heroin
morphine
Transcribed Image Text:1. Morphine (below) is a natural product isolated from. interacts with the µ opioid receptor (MOR) in the central nervous system as an agonist. What does it mean to be an agonist? It 2. Morphine can be converted to Heroin (below) by treatment with X - put the reagent in the box below. но. H3C N-CH3 N--CH3 HO H3C morphine heroin Heroin is a pro-drug of morphine, which is more rapidly taken up into the brain than morphine, but once inside of the brain converts to morphine due to esterase enzymes. 3. Provide the mechanism for the conversion of heroin to morphine below using hydroxide. You only need to show the mechanism for the hydrolysis of one of the esters. H3C. но. NaOH „N~CH, H20 N--CHs HO heroin morphine
4. Provide the mechanism for the conversion of heroin to morphine below using only the esterase
enzyme and water (B: is a basic group). You only need to show the mechanism for the hydrolysis of
one of the esters. Hint: there will be a covalent intermediate with the enzyme.
H3C.
но.
esterase
O H-
N~CH, H,0
N~-CHs
H3C
HO
heroin
morphine
5. Naloxone is a reversal agent used to prevent death from occurring upon overdose of heroin.
Draw the structure of naloxone in the box below - draw the structure so that the similarity with
morphine is obvious. How is naloxone a reversal agent?
Transcribed Image Text:4. Provide the mechanism for the conversion of heroin to morphine below using only the esterase enzyme and water (B: is a basic group). You only need to show the mechanism for the hydrolysis of one of the esters. Hint: there will be a covalent intermediate with the enzyme. H3C. но. esterase O H- N~CH, H,0 N~-CHs H3C HO heroin morphine 5. Naloxone is a reversal agent used to prevent death from occurring upon overdose of heroin. Draw the structure of naloxone in the box below - draw the structure so that the similarity with morphine is obvious. How is naloxone a reversal agent?
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