In the mevalonate pathway, three acetyl-CoA are combined to give a C5 product, IPP. A. Write out a 5-step general acid/general base mechanism to explain how HMG-CoA is formed from 3 acetyl-CoA (Note: we are leaving out some details. The enzyme HMG-CoA actually uses its Cys residues to accept acetyl groups from 2 acetyl-CoA, making new thioesters and liberating CoASH) B. Two NADPH and two H+ are required to form mevalonic acid from HMG-CoA. Circle the H atoms that came from NADPH, and put a square around any H atoms that came from H+ C. Three ATP are used to convert mevalonic acid to IPP. Explain the role of each ATP molecule

In the mevalonate pathway, three acetyl-CoA are combined to give a C5 product, IPP. A. Write out a 5-step general acid/general base mechanism to explain how HMG-CoA is formed from 3 acetyl-CoA (Note: we are leaving out some details. The enzyme HMG-CoA actually uses its Cys residues to accept acetyl groups from 2 acetyl-CoA, making new thioesters and liberating CoASH) B. Two NADPH and two H+ are required to form mevalonic acid from HMG-CoA. Circle the H atoms that came from NADPH, and put a square around any H atoms that came from H+ C. Three ATP are used to convert mevalonic acid to IPP. Explain the role of each ATP molecule

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter29: The Organic Chemistry Of Metabolic Pathways

Section29.SE: Something Extra

Problem 53AP

See similar textbooks

Similar questions

In the 1st reaction of citric acid cycle, acetyl CoA and oxaloacetate are combined to form citrate as shown below. What is the best way to describe this reaction? CH acetyl Col CH₂ co exaloncertate HO citrate synthase ço, CH₂ HO-C-00 CH₂ co₂ citrate O It begins with an Aldol reaction followed by hydrolysis of CoA thioester). It begins with a keto-enol tautomerization followed by an Aldol reaction. It involves a Claisen condentation. OIt involves an Aldol condensation. None of the above
1. Provide a reasonable step-wise mechanism for the reaction below, involving FAD as a coenzyme and invoking any general acids and bases from acyl-CoA dehydrogenase that you might need (just draw the tricyclic flavin core of FAD; no need to show the ribitol or ADP, R + FAD SCOA acyl-CoA dehydrogenase R SCOA + FADH₂
← Draw the product of the reaction of acetyl CoA with ACP-SH catalyzed by malonyl-CoA-acetyl-CoA-ACP transacylase (MAT). Provide the structure in the protonation state found in physiological conditions. malonyl-CoA-acetyl-CoA-ACP transacylase (MAT) SCOA Drawing o
None
Lysine catabolism begins with reductive amination of a-ketoglutarate to give saccharopine in a multistep process. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. Arrow-pushing Instructions 7 COO H NH3 COO OOC B: COO H NH3 COO BH+
5. In the subsequent stages of glycolysis (see figure below): (1) cleavage of FBP to dihydroxyacetone (DHP) and glyceraldehyde 3-phosphate (G3P) according to FBP → DHP + G3P is catalyzed by aldolase with K₁ = 104 and (2) the DHP and G3P can interconvert (DHP → G3P), a process catalyzed by triose phosphate isomerase with K₂ = 0.040. If a 1.75 mM solution of FBP is treated with both of these enzymes (enabling both of these reactions) at pH 7 and 37°C, find the resulting equilibrium concentration of each species.
4. The AGo for the aldolase reaction is 22.8 kJ/mol. When the reaction is run in a hepatocyte cell at 37°C, the concentrations of the intermediates are: fructose 1,6-bisphosphate =1.41 x 103 M, glyceraldehyde 3-phosphate 2.95 x 10-6 M, and dihydroxyacetone phosphate = 1.62 x 10-5 M. Calculate the free energy change for this reaction Is this reaction thermodynamically favorable
a Lactate dehydrogenase H H3C-C-coO- ОН ooc-C-CH3 L-(+)-Lactase Pyruvate This is a(an) b Creatine kinase CH3 O CH3 O H2N, АТР ADP NH2 NH2 Adenosine triphosphate Adenosine diphosphate Creatine Phosphocreatine This is a(an)
can you tell me step by step, what is happening to convert L-luciferin to D-luciferin? the chemistru behind it vur IvatuvI conditions. H,N COOH DOH .COOH HS L-cysteine L-luciferin D-luciferin Luciferyl-CoA synthase (Luciferase) ATP, Mg, COA OH -COA COA -COA L-luciferyl-CoA (enol) D-luciferyl-CoA hydrolysis hydrolysis enzyme enzyme COOH HO L-luciferin D-luciferin Download : Download full-size image
Draw the complete, step-wise mechanism of a phosphate transfer reaction that follows a concerted pathway or SN2 type reaction pathway. Clearly depict the transition state of the reaction.. R₁ B: ti R2 ert
Draw curved arrows to show the mechanism for the step of the B-ketoacyl-ACP synthase reaction shown below. Arrow-pushing Instructions :0: :0: :0: :0: LACP ACP H2C H2 :ö:
Draw curved arrows to show the mechanism for the step of the HMG-synthase reaction shown below. Arrow-pushing Instructions H. :0: :OH :ÖH :0: CoA COA COA но ČH3 :OH ČH3 CoA