In the mevalonate pathway, three acetyl-CoA are combined to give a C5 product, IPP. A. Write out a 5-step general acid/general base mechanism to explain how HMG-CoA is formed from 3 acetyl-CoA (Note: we are leaving out some details. The enzyme HMG-CoA actually uses its Cys residues to accept acetyl groups from 2 acetyl-CoA, making new thioesters and liberating CoASH) B. Two NADPH and two H+ are required to form mevalonic acid from HMG-CoA. Circle the H atoms that came from NADPH, and put a square around any H atoms that came from H+ C. Three ATP are used to convert mevalonic acid to IPP. Explain the role of each ATP molecule

In the mevalonate pathway, three acetyl-CoA are combined to give a C5 product, IPP. A. Write out a 5-step general acid/general base mechanism to explain how HMG-CoA is formed from 3 acetyl-CoA (Note: we are leaving out some details. The enzyme HMG-CoA actually uses its Cys residues to accept acetyl groups from 2 acetyl-CoA, making new thioesters and liberating CoASH) B. Two NADPH and two H+ are required to form mevalonic acid from HMG-CoA. Circle the H atoms that came from NADPH, and put a square around any H atoms that came from H+ C. Three ATP are used to convert mevalonic acid to IPP. Explain the role of each ATP molecule

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter29: The Organic Chemistry Of Metabolic Pathways

Section29.SE: Something Extra

Problem 53AP

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