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Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction. 2-O,POOH dihydroxyacetone phosphate I OH triosephosphate isomerase 2-03PO H FYI Glu is glutamic acid and his is histadine glyceraldehyde-3-phosphate

Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction. 2-O,POOH dihydroxyacetone phosphate I OH triosephosphate isomerase 2-03PO H FYI Glu is glutamic acid and his is histadine glyceraldehyde-3-phosphate

Organic Chemistry
Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter29: The Organic Chemistry Of Metabolic Pathways
Section29.SE: Something Extra
Problem 24MP: One of the steps in the pentose phosphate pathway for glucose catabolism is the reaction of xylulose...
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Please draw by hand. Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction. ОН 2-03Р0 ОН dihydroxyacetone phosphate triosephosphate isomerase 2-03РО. H glyceraldehyde-3-phosphate FYI Glu is glutamic acid and his is histadine
Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction. 2-O,POOH dihydroxyacetone phosphate I OH triosephosphate isomerase 2-03PO H FYI Glu is glutamic acid and his is histadine glyceraldehyde-3-phosphate
Transcribed Image Text:Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction. 2-O,POOH dihydroxyacetone phosphate I OH triosephosphate isomerase 2-03PO H FYI Glu is glutamic acid and his is histadine glyceraldehyde-3-phosphate
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