In the lab, metabolic poisons can be used to study ATP synthesis and oxygen consumption. Many of these poisons have - or have had - other uses, from diet aids to animal poisons to antibiotics. Poison oligomycin cyanide trifluorocarbonylcyanide phenylhydrazone (FCCP) rotenone bongkrekic acid Action binds to Fo and blocks the proton channel inhibits cytochrome oxidase by reacting with heme a3 increases membrane proton permeability blocks electron transfer at NADH dehydrogenase (NAD-Q oxidoreductase) binds to inward-facing site of ATP-ADP translocase Classify the metabolic poisons as electron transport inhibitors, uncoupling agents, ATP synthase inhibitors, or transport inhibitors. Electron transport inhibitors Uncoupling agents, ionophores ATP synthase inhibitors Transport inhibitors rotenone oligomycin cyanide bongkrekic acid FCCP

Biology Today and Tomorrow without Physiology (MindTap Course List)
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Chapter4: Energy And Metabolism
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In the lab, metabolic poisons can be used to study ATP synthesis and oxygen consumption. Many of these poisons have - or
have had - other uses, from diet aids to animal poisons to antibiotics.
Poison
oligomycin
cyanide
trifluorocarbonylcyanide phenylhydrazone
(FCCP)
rotenone
bongkrekic acid
Action
binds to Fo and blocks the proton channel
inhibits cytochrome oxidase by reacting with heme a3
increases membrane proton permeability
blocks electron transfer at NADH dehydrogenase
(NAD-Q oxidoreductase)
binds to inward-facing site of ATP-ADP translocase
Classify the metabolic poisons as electron transport inhibitors, uncoupling agents, ATP synthase inhibitors, or
transport inhibitors.
Electron
transport inhibitors
Uncoupling agents,
ionophores
ATP synthase inhibitors
Transport inhibitors
rotenone
oligomycin
cyanide
bongkrekic acid
FCCP
Transcribed Image Text:In the lab, metabolic poisons can be used to study ATP synthesis and oxygen consumption. Many of these poisons have - or have had - other uses, from diet aids to animal poisons to antibiotics. Poison oligomycin cyanide trifluorocarbonylcyanide phenylhydrazone (FCCP) rotenone bongkrekic acid Action binds to Fo and blocks the proton channel inhibits cytochrome oxidase by reacting with heme a3 increases membrane proton permeability blocks electron transfer at NADH dehydrogenase (NAD-Q oxidoreductase) binds to inward-facing site of ATP-ADP translocase Classify the metabolic poisons as electron transport inhibitors, uncoupling agents, ATP synthase inhibitors, or transport inhibitors. Electron transport inhibitors Uncoupling agents, ionophores ATP synthase inhibitors Transport inhibitors rotenone oligomycin cyanide bongkrekic acid FCCP
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