In mice, the autosomal locus coding for the β-globinchain of hemoglobin is 1 m.u. from the albino locus. Assume for the moment that the same is true in humans. The disease sickle-cell anemia is the result ofhomozygosity for a particular mutation in theβ-globin gene.a. A son is born to an albino man and a woman withsickle-cell anemia. What kinds of gametes will theson form, and in what proportions?b. A daughter is born to a normal man and a womanwho has both albinism and sickle-cell anemia.What kinds of gametes will the daughter form,and in what proportions?c. If the son in part (a) grows up and marries thedaughter in part (b), what is the probability that achild of theirs will be an albino with sickle-cellanemia?
In mice, the autosomal locus coding for the β-globin
chain of hemoglobin is 1 m.u. from the albino locus. Assume for the moment that the same is true in humans. The disease sickle-cell anemia is the result of
homozygosity for a particular mutation in the
β-globin gene.
a. A son is born to an albino man and a woman with
sickle-cell anemia. What kinds of gametes will the
son form, and in what proportions?
b. A daughter is born to a normal man and a woman
who has both albinism and sickle-cell anemia.
What kinds of gametes will the daughter form,
and in what proportions?
c. If the son in part (a) grows up and marries the
daughter in part (b), what is the probability that a
child of theirs will be an albino with sickle-cell
anemia?
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