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--- **Genetic Disorders and Inheritance Patterns** Some rare human genetic disorders have an inheritance pattern similar to the one seen in the pedigree below. ![Pedigree Diagram] **Description of the Pedigree:** - **I.** The first generation shows one affected individual (solid black symbol) married to an unaffected individual (white symbol), and they have offspring. - **II.** The second generation includes multiple children, where some are affected and some are unaffected. Two affected individuals among these children marry unaffected individuals. - **III.** In the third generation, the affected individuals continue to pass on the disorder to the next generation, resulting in a mix of affected and unaffected individuals among the grandchildren. - **IV.** The fourth generation shows the great-grandchildren with some affected and unaffected individuals. **a.) How would you describe this mode of inheritance?** This mode of inheritance suggests an **autosomal dominant** pattern. Each generation has affected individuals, and both males and females are equally affected, indicating the disorder is not sex-linked. Affected individuals typically have one affected parent, confirming the dominant nature of the trait. **b.) How would you explain the genetic nature of this rare disorder?** In an autosomal dominant disorder, only one copy of the altered gene is necessary for an individual to be affected. This altered gene is located on one of the non-sex chromosomes (autosomes). Affected parents have a 50% chance of passing the disorder to their offspring with each pregnancy, irrespective of the child’s sex. ---

--- **Genetic Disorders and Inheritance Patterns** Some rare human genetic disorders have an inheritance pattern similar to the one seen in the pedigree below. ![Pedigree Diagram] **Description of the Pedigree:** - **I.** The first generation shows one affected individual (solid black symbol) married to an unaffected individual (white symbol), and they have offspring. - **II.** The second generation includes multiple children, where some are affected and some are unaffected. Two affected individuals among these children marry unaffected individuals. - **III.** In the third generation, the affected individuals continue to pass on the disorder to the next generation, resulting in a mix of affected and unaffected individuals among the grandchildren. - **IV.** The fourth generation shows the great-grandchildren with some affected and unaffected individuals. **a.) How would you describe this mode of inheritance?** This mode of inheritance suggests an **autosomal dominant** pattern. Each generation has affected individuals, and both males and females are equally affected, indicating the disorder is not sex-linked. Affected individuals typically have one affected parent, confirming the dominant nature of the trait. **b.) How would you explain the genetic nature of this rare disorder?** In an autosomal dominant disorder, only one copy of the altered gene is necessary for an individual to be affected. This altered gene is located on one of the non-sex chromosomes (autosomes). Affected parents have a 50% chance of passing the disorder to their offspring with each pregnancy, irrespective of the child’s sex. ---

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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--- **Genetic Disorders and Inheritance Patterns** Some rare human genetic disorders have an inheritance pattern similar to the one seen in the pedigree below. ![Pedigree Diagram] **Description of the Pedigree:** - **I.** The first generation shows one affected individual (solid black symbol) married to an unaffected individual (white symbol), and they have offspring. - **II.** The second generation includes multiple children, where some are affected and some are unaffected. Two affected individuals among these children marry unaffected individuals. - **III.** In the third generation, the affected individuals continue to pass on the disorder to the next generation, resulting in a mix of affected and unaffected individuals among the grandchildren. - **IV.** The fourth generation shows the great-grandchildren with some affected and unaffected individuals. **a.) How would you describe this mode of inheritance?** This mode of inheritance suggests an **autosomal dominant** pattern. Each generation has affected individuals, and both males and females are equally affected, indicating the disorder is not sex-linked. Affected individuals typically have one affected parent, confirming the dominant nature of the trait. **b.) How would you explain the genetic nature of this rare disorder?** In an autosomal dominant disorder, only one copy of the altered gene is necessary for an individual to be affected. This altered gene is located on one of the non-sex chromosomes (autosomes). Affected parents have a 50% chance of passing the disorder to their offspring with each pregnancy, irrespective of the child’s sex. ---
Transcribed Image Text:--- **Genetic Disorders and Inheritance Patterns** Some rare human genetic disorders have an inheritance pattern similar to the one seen in the pedigree below. ![Pedigree Diagram] **Description of the Pedigree:** - **I.** The first generation shows one affected individual (solid black symbol) married to an unaffected individual (white symbol), and they have offspring. - **II.** The second generation includes multiple children, where some are affected and some are unaffected. Two affected individuals among these children marry unaffected individuals. - **III.** In the third generation, the affected individuals continue to pass on the disorder to the next generation, resulting in a mix of affected and unaffected individuals among the grandchildren. - **IV.** The fourth generation shows the great-grandchildren with some affected and unaffected individuals. **a.) How would you describe this mode of inheritance?** This mode of inheritance suggests an **autosomal dominant** pattern. Each generation has affected individuals, and both males and females are equally affected, indicating the disorder is not sex-linked. Affected individuals typically have one affected parent, confirming the dominant nature of the trait. **b.) How would you explain the genetic nature of this rare disorder?** In an autosomal dominant disorder, only one copy of the altered gene is necessary for an individual to be affected. This altered gene is located on one of the non-sex chromosomes (autosomes). Affected parents have a 50% chance of passing the disorder to their offspring with each pregnancy, irrespective of the child’s sex. ---
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