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2. DNA profiles can be used to identify unknown victims from a natural disaster. A DNA sample from a toothbrush of a potential victim had the genotype A¡A4B2B3C4C5D¡D1. Remains from an unidentified victim were found to have the same genotype. Given the allele frequencies in the relevant population in the table below: a) What is the probability that these two samples matches by chance? b) List two assumptions you made in answering this question. Locus allele A C 1 0.2 0.1 0.15 0.7 0.1 0.1 0.1 0.6 0.3 0.05 0.1 0.25 0.05 0.3 0.40 0.15 0.35 N345

2. DNA profiles can be used to identify unknown victims from a natural disaster. A DNA sample from a toothbrush of a potential victim had the genotype A¡A4B2B3C4C5D¡D1. Remains from an unidentified victim were found to have the same genotype. Given the allele frequencies in the relevant population in the table below: a) What is the probability that these two samples matches by chance? b) List two assumptions you made in answering this question. Locus allele A C 1 0.2 0.1 0.15 0.7 0.1 0.1 0.1 0.6 0.3 0.05 0.1 0.25 0.05 0.3 0.40 0.15 0.35 N345

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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2. DNA profiles can be used to identify unknown victims from a natural disaster. A DNA sample from a toothbrush of a potential victim had the genotype A1A4B2B3C4C5D¡D1. Remains from an unidentified victim were found to have the same genotype. Given the allele frequencies in the relevant population in the table below: a) What is the probability that these two samples matches by chance? b) List two assumptions you made in answering this question. Locus allele A C D 1 0.2 0.1 0.15 0.7 2 0.1 0.6 0.1 0.3 3 0.05 0.1 0.1 4 0.25 0.05 0.3 5 0.40 0.15 0.35
Transcribed Image Text:2. DNA profiles can be used to identify unknown victims from a natural disaster. A DNA sample from a toothbrush of a potential victim had the genotype A1A4B2B3C4C5D¡D1. Remains from an unidentified victim were found to have the same genotype. Given the allele frequencies in the relevant population in the table below: a) What is the probability that these two samples matches by chance? b) List two assumptions you made in answering this question. Locus allele A C D 1 0.2 0.1 0.15 0.7 2 0.1 0.6 0.1 0.3 3 0.05 0.1 0.1 4 0.25 0.05 0.3 5 0.40 0.15 0.35
1. The pedigree below shows the incidence of rare, autosomal dominant disorder called Ehlers-Danlos disease. The pedigree covers three generations of a particular family and also shows individual genotypes at a potential marker locus (M). a) Indicate the phase of all gen II and III individuals. DdM1M3 ddM2M6 II DDM3M6 ddM4M5 III DdMзM4 DdMЗМ5 DDM3M4 ddM3M5 DDM3M4 ddM5M6 DDM3M4 ddM4M6 ddM5M6 ddM5M6 b) Which, if any, of the gen III individuals are recombinants? c) Calculate the LOD score as a test of physical linkage between the marker (M) and the disease locus. d) What do you conclude about linkage between D and M?
Transcribed Image Text:1. The pedigree below shows the incidence of rare, autosomal dominant disorder called Ehlers-Danlos disease. The pedigree covers three generations of a particular family and also shows individual genotypes at a potential marker locus (M). a) Indicate the phase of all gen II and III individuals. DdM1M3 ddM2M6 II DDM3M6 ddM4M5 III DdMзM4 DdMЗМ5 DDM3M4 ddM3M5 DDM3M4 ddM5M6 DDM3M4 ddM4M6 ddM5M6 ddM5M6 b) Which, if any, of the gen III individuals are recombinants? c) Calculate the LOD score as a test of physical linkage between the marker (M) and the disease locus. d) What do you conclude about linkage between D and M?
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