In chymotrypsin, a mutant was constructed with Ser 189, which is at the bottom of the substrate-specificity pocket, changed to Lys. What effect would you predict for this Ser 189 → Lys 189 mutation?
In chymotrypsin, a mutant was constructed with Ser 189, which is at the bottom of the substrate-specificity pocket, changed to Lys. What effect would you predict for this Ser 189 → Lys 189 mutation?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Chymotrypsin is a digestive enzyme that is produced in the pancreas and plays an important role in the breakdown of proteins during the digestive process. It belongs to a family of enzymes called serine proteases and is primarily responsible for cleaving peptide bonds on the carboxyl side of large hydrophobic amino acids such as phenylalanine, tryptophan, and tyrosine.
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