If you wanted to improve the catalytic efficiency of an enzyme, would you mutate amino acid residues to increase/decrease binding affinity for the substrate, or to increase/decrease the binding of the transition state? Explain. Mutate amino acids to increase binding to the transition state because it increases the activation energy; mutations that bind substrate more tightly decrease the activation energy. Mutate amino acids to decrease binding to the transition state because it increases the activation energy; mutations that bind substrate more tightly decrease the activation energy. Mutate amino acids to increase binding to the transition state because it decreases the activation energy; mutations that bind substrate more tightly increase the activation energy. Mutate amino acids to increase binding to the substrate bind because it decreases the activation energy; mutations that bind the transition state more tightly increase the activation energy.
If you wanted to improve the catalytic efficiency of an enzyme, would you mutate amino acid residues to increase/decrease binding affinity for the substrate, or to increase/decrease the binding of the transition state? Explain. Mutate amino acids to increase binding to the transition state because it increases the activation energy; mutations that bind substrate more tightly decrease the activation energy. Mutate amino acids to decrease binding to the transition state because it increases the activation energy; mutations that bind substrate more tightly decrease the activation energy. Mutate amino acids to increase binding to the transition state because it decreases the activation energy; mutations that bind substrate more tightly increase the activation energy. Mutate amino acids to increase binding to the substrate bind because it decreases the activation energy; mutations that bind the transition state more tightly increase the activation energy.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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