Which of the following are characteristics of catabolic metabolic pathways? (Choose all correct answers). Overall oxidation of initial substrates so redox reactions involve use of NAD+ as oxidizing agent, converted to NADH. Large initial substrates are broken down to smaller final products. Overall reduction of intial substrates so redox reactions involve use of NADPH as reducing agent, converted to NADP+. The pathways are overall exergonic (negative delta G). Net production of ATP as a result of the pathway. Essentially irreversible

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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### Characteristics of Catabolic Metabolic Pathways

When analyzing catabolic metabolic pathways, several key characteristics are commonly observed. Below are the options with the correct ones identified:

- ☐ **Overall oxidation of initial substrates so redox reactions involve use of NAD+ as oxidizing agent, converted to NADH.**
- ☑ **Large initial substrates are broken down to smaller final products.**
- ☐ **Overall reduction of initial substrates so redox reactions involve use of NADPH as reducing agent, converted to NADP+.**
- ☑ **The pathways are overall exergonic (negative delta G).**
- ☑ **Net production of ATP as a result of the pathway.**
- ☒ **Essentially irreversible**

In summary, the catabolic metabolic pathways are characterized by the breakdown of large initial substrates into smaller final products and are generally exergonic, leading to a net production of ATP.
Transcribed Image Text:### Characteristics of Catabolic Metabolic Pathways When analyzing catabolic metabolic pathways, several key characteristics are commonly observed. Below are the options with the correct ones identified: - ☐ **Overall oxidation of initial substrates so redox reactions involve use of NAD+ as oxidizing agent, converted to NADH.** - ☑ **Large initial substrates are broken down to smaller final products.** - ☐ **Overall reduction of initial substrates so redox reactions involve use of NADPH as reducing agent, converted to NADP+.** - ☑ **The pathways are overall exergonic (negative delta G).** - ☑ **Net production of ATP as a result of the pathway.** - ☒ **Essentially irreversible** In summary, the catabolic metabolic pathways are characterized by the breakdown of large initial substrates into smaller final products and are generally exergonic, leading to a net production of ATP.
**Question:**
Which of the following types of inhibitors will bind to both the free enzyme and the enzyme-substrate complex?

**Options:**
- Noncompetitive
- Uncompetitive
- Competitive
- Mixed Inhibitor

**Answer:**
- Noncompetitive (checked)
- Mixed Inhibitor (checked)

In this multiple-choice question, users are asked to identify which types of enzyme inhibitors will bind to both the free enzyme and the enzyme-substrate complex. The correct answers, as indicated by the check marks, are "Noncompetitive" and "Mixed Inhibitor."

### Explanation:
- **Noncompetitive Inhibitor:** This type of inhibitor can bind to an enzyme regardless of whether the enzyme has already bound to the substrate. This binding typically occurs at an allosteric site rather than at the active site, which leads to inhibition of enzyme activity.
- **Mixed Inhibitor:** A mixed inhibitor resembles a noncompetitive inhibitor in that it can also bind to both the free enzyme and the enzyme-substrate complex. However, its effect on enzyme activity is more complex, as it can increase or decrease the enzyme's affinity for its substrate.

Understanding the differences between these types of inhibitors is essential for comprehending enzyme regulation and drug design in biochemistry and pharmacology.
Transcribed Image Text:**Question:** Which of the following types of inhibitors will bind to both the free enzyme and the enzyme-substrate complex? **Options:** - Noncompetitive - Uncompetitive - Competitive - Mixed Inhibitor **Answer:** - Noncompetitive (checked) - Mixed Inhibitor (checked) In this multiple-choice question, users are asked to identify which types of enzyme inhibitors will bind to both the free enzyme and the enzyme-substrate complex. The correct answers, as indicated by the check marks, are "Noncompetitive" and "Mixed Inhibitor." ### Explanation: - **Noncompetitive Inhibitor:** This type of inhibitor can bind to an enzyme regardless of whether the enzyme has already bound to the substrate. This binding typically occurs at an allosteric site rather than at the active site, which leads to inhibition of enzyme activity. - **Mixed Inhibitor:** A mixed inhibitor resembles a noncompetitive inhibitor in that it can also bind to both the free enzyme and the enzyme-substrate complex. However, its effect on enzyme activity is more complex, as it can increase or decrease the enzyme's affinity for its substrate. Understanding the differences between these types of inhibitors is essential for comprehending enzyme regulation and drug design in biochemistry and pharmacology.
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