ATP levels are high in the liver, NADPH levels are low, but fat biosynthesis needs to happen. What is the function of the pentose phosphate pathway?
ATP levels are high in the liver, NADPH levels are low, but fat biosynthesis needs to happen. What is the function of the pentose phosphate pathway?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
ATP levels are high in the liver, NADPH levels are low, but fat biosynthesis needs to happen. What is the function of the pentose phosphate pathway?
Mode 1 - NADPH and ribose 5-phosphate are being generated
Mode 2 - ribose 5-phosphate is needed, so only the non-oxidative portion is being used for carbon skeleton rearrangments
Mode 3 - NADPH is needed, so oxidative portion is operating to make NADPH and non-oxidative portion is operating to regenerate glucose 6-phosphate
Mode 4 - NADPH and ATP are needed, so oxidative portion makes NADPH, non-oxidative portion does carbon skeleton rearrangements to fuel glycolysis and make ATP
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Step 1
The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P).
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