1a. If you wanted you could take a glucose molecule and convert it to pyruvate via glycolysis and convert it back to glucose via gluconeogenesis. What is the cost of doing so in ATP equivalents? Show how you determine the cost via reactions (no structures).
1a. If you wanted you could take a glucose molecule and convert it to pyruvate via glycolysis and convert it back to glucose via gluconeogenesis. What is the cost of doing so in ATP equivalents? Show how you determine the cost via reactions (no structures).
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question

Transcribed Image Text:1a.
If you wanted you could take a glucose molecule and convert it to pyruvate via glycolysis
and convert it back to glucose via gluconeogenesis. What is the cost of doing so in ATP equivalents?
Show how you determine the cost via reactions (no structures).
Explain in bioenergetic terms how the conversion of pyruvate to phosphoenolpyruvate in
gluconeogenesis overcomes the large, negative standard free- energy change of the pyruvate kinase
reaction in glycolysis.
b.
C.
The consumption of alcohol (ethanol), especially after periods of strenuous activity or after
not eating for several hours, results in a deficiency of glucose in the blood, a condition known as
hypoglycemia. The first step in the metabolism of ethanol by the liver is oxidation to acetaldehyde,
catalyzed by liver alcohol dehydrogenase:
CH3CH2OH + NAD+ -> CH3CHO + NADH + H+
Explain how this reaction inhibits the transformation of lactate to pyruvate. Why does this lead to
hypoglycemia?
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