A newly developed drug is suspected to act by inhibiting its enzymatic target. To test this, the rates of reaction in the presence and absence of the new drug were determined. The results of these experiments have been plotted as a double reciprocal plot shown in figure 1 below. Using this figure, calculate the values of Vmax and Km for the enzyme in the presence and absence of the drug. 2. Based on the figure and your answer, what type of inhibition is the new drug displaying? 3. Briefly explain how this type of inhibition exerts its action on an enzyme. Figure 1: Double reciprocal plot of reaction rate against substrate concentration in the presence and absence of a new drug.
A newly developed drug is suspected to act by inhibiting its enzymatic target. To test this, the rates of reaction in the presence and absence of the new drug were determined. The results of these experiments have been plotted as a double reciprocal plot shown in figure 1 below. Using this figure, calculate the values of Vmax and Km for the enzyme in the presence and absence of the drug. 2. Based on the figure and your answer, what type of inhibition is the new drug displaying? 3. Briefly explain how this type of inhibition exerts its action on an enzyme. Figure 1: Double reciprocal plot of reaction rate against substrate concentration in the presence and absence of a new drug.
Chapter5: Unit, Percentage, Milliequivalent, Ratio, And Household Measures
Section: Chapter Questions
Problem 1.4P
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- A newly developed drug is suspected to act by inhibiting its enzymatic target. To test this, the rates of reaction in the presence and absence of the new drug were determined. The results of these experiments have been plotted as a double reciprocal plot shown in figure 1 below.
- Using this figure, calculate the values of Vmax and Km for the enzyme in the presence and absence of the drug.
2. Based on the figure and your answer, what type of inhibition is the new drug displaying?
3. Briefly explain how this type of inhibition exerts its action on an enzyme.
Figure 1: Double reciprocal plot of
![140
With new drug
120
100
80
60
Without new drug
40
20
-250
-200
-150
-100
-50
50
100
1/[S] (mM)
(s/wri)°A /I](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F30074c77-d2a0-4f97-82b5-3e00e9431cf7%2Fe35616c8-2adc-4be7-872c-d1561cc735ce%2Fb3z1gwr_processed.png&w=3840&q=75)
Transcribed Image Text:140
With new drug
120
100
80
60
Without new drug
40
20
-250
-200
-150
-100
-50
50
100
1/[S] (mM)
(s/wri)°A /I
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