Huntington disease (HD) is a rare dominant condition in humans that results in a slow but inexorable deterioration of the nervous system. HD shows what might be called “age-dependent penetrance,” which is to say that the probability that a person with the HD genotype will express the phenotype varies with age. Assume that 50% of those inheriting the HD allele will express the symptoms by age 40. Susan is a 35-year-old woman whose father has HD. She currently shows no symptoms. What is the probability that Susan will show symptoms in five years?
Huntington disease (HD) is a rare dominant condition in humans that results in a slow but inexorable deterioration of the nervous system. HD shows what might be called “age-dependent penetrance,” which is to say that the probability that a person with the HD genotype will express the phenotype varies with age. Assume that 50% of those inheriting the HD allele will express the symptoms by age 40. Susan is a 35-year-old woman whose father has HD. She currently shows no symptoms. What is the probability that Susan will show symptoms in five years?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Huntington disease (HD) is a rare dominant
condition in humans that results in a slow but
inexorable deterioration of the nervous
system. HD shows what might be called
“age-dependent penetrance,” which is to say
that the probability that a person with the HD
genotype will express the
with age. Assume that 50% of those
inheriting the HD allele will express the
symptoms by age 40. Susan is a 35-year-old
woman whose father has HD. She currently
shows no symptoms. What is the probability
that Susan will show symptoms in five years?
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